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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Recent Developments in the Pharmacological Properties of 4'-Geranyloxyferulic Acid, a Colon Cancer Chemopreventive Agent of Natural Origin

Author(s): Salvatore Genovese and Francesco Epifano

Volume 13, Issue 8, 2012

Page: [1083 - 1088] Pages: 6

DOI: 10.2174/138945012802009008

Price: $65

Abstract

3-(4'-Geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid (4'-geranyloxyferulic acid, GOFA) is a secondary metabolite biosynthetically related to ferulic acid in which a geranyl chain is attached to the phenolic group, extracted in 1966 from Acronychia baueri Schott (Fam. Rutaceae). In the last decade the pharmacological properties of the title compound began to be characterized, revealing its good activity as anti-inflammatory and dietary feeding cancer chemopreventive agent. The aim of this review is to examine in detail the recently reported properties of 4'-geranyloxyferulic acid from a chemical and pharmacological point of view, including the recent acquisition about its mechanism of action.

Keywords: Anti-cancer activity, anti-inflammatory activity, cancer chemoprevention, prenyloxycinnamic acids, rutaceae, geranyl chain, 4'-geranyloxyferulic acid, anti-inflammatory, neuroprotective effects, GOFA


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