Abstract
3-n-Butylphthalide (1) and its analogues, which are the main components in the volatile oil of celery as well as a wide range of umbelliferae and composite plants, have potential applications as hypotensive drugs because of their strong pharmacological activities, such as improving the microcirculatory system of mans brain, improving nervous function deficiency, antiasthma, anticonvulsion, inhibiting platelet aggregation, inhibiting prostaglandin (PG) F2a growth, enhancing blood flow volume, antitumorigenesis, hypotensive activity and so on, so the investigation on the syntheses and applications of them has attracted considerable attention. The significant synthetic methods of 3-n-butylphthalide and its analogues were summarized and discussed in this review and it is expected that it may be valuable for their further development and applications.
Keywords: Benzoyl Chloride, o-Bromobenzaldehyde, Enyne-Diyne System, Chiral Phthalide, 3-Butylidenephthalide
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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