2,4,6-Trichlorophenylhydrazine Schiff Bases as DPPH Radical and Super Oxide Anion Scavengers

Title:2,4,6-Trichlorophenylhydrazine Schiff Bases as DPPH Radical and Super Oxide Anion Scavengers

Volume: 8 Issue: 3

Author(s): Khalid Mohammed Khan, Zarbad Shah, Viqar Uddin Ahmad, Momin Khan, Muhammad Taha, Fazal Rahim, Sajjad Ali, Nida Ambreen, Shahnaz Perveen, M. Iqbal Choudhary and Wolfgang Voelter

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Keywords: 2, 4, 6-Trichlorophenylhydrazine Schiff bases, DPPH radical, superoxide anion scavengers, trichlorophenylhydrazine, radical scavenging, propylgallate, antituberculosis, antifungal, rodenticides

Abstract: Syntheses of thirty 2,4,6-trichlorophenylhydrazine Schiff bases 1-30 were carried out and evaluated for their in vitro DPPH radical and super oxide anion scavenging activities. Compounds 1-30 have shown a varying degree of DPPH radical scavenging activity and their IC50 values range between 4.05-369.30 µM. The compounds 17, 28, 18, 14, 8, 15, 12, 2, 29, and 7 exhibited IC50 values ranging between 4.05 ± 0.06-24.42 ± 0.86 µM which are superior to standard n-propylgallate (IC50 = 30.12 ± 0.27 µM). Selected compounds have shown a varying degree of superoxide anion radical scavenger activity and their IC50 values range between 91.23-406.90 µM. The compounds 28 8, 17, 15, and 14, showed IC50 values between 91.23 ± 1.2-105.31 ± 2.29 µM which are superior to standard n-propylgallate (IC50 = 106.34 ± 1.6 µM).

Cite this article as:

Mohammed Khan Khalid, Shah Zarbad, Uddin Ahmad Viqar, Khan Momin, Taha Muhammad, Rahim Fazal, Ali Sajjad, Ambreen Nida, Perveen Shahnaz, Iqbal Choudhary M. and Voelter Wolfgang, 2,4,6-Trichlorophenylhydrazine Schiff Bases as DPPH Radical and Super Oxide Anion Scavengers, Medicinal Chemistry 2012; 8 (3) . https://dx.doi.org/10.2174/1573406411208030452