Abstract
In this review we critically examine PI (Padmakar-Ivan) index of organic compounds acting as drugs and discussed its applications in Computer-Aided designing of bioactive compounds with special reference to designing of carbonic anhydrase inhibitors, lipophilicity, toxicity, tadpole narcosis, bio-concentration factor, diuretic activity and carcinogenic activity of aromatic hydrocarbons and heterocycles etc.
Keywords: PI index, computer-aided drug design, bioactive compound, QSAR, QSPR, QSTR, regression analysis, carbonic, anhydrace inhibitor, lipophilicity
Current Bioactive Compounds
Title: Use of PI Index in Computer-Aided Designing of Bioactive Compounds
Volume: 2 Issue: 1
Author(s): Padmakar V. Khadikar, Mircea V. Diudea, Jyoti Singh, Peter E. John, Anjalee Shrivastva, Shalini Singh, Sneha Karmarkar, Meenakshi Lakhwani and Purnima Thakur
Affiliation:
Keywords: PI index, computer-aided drug design, bioactive compound, QSAR, QSPR, QSTR, regression analysis, carbonic, anhydrace inhibitor, lipophilicity
Abstract: In this review we critically examine PI (Padmakar-Ivan) index of organic compounds acting as drugs and discussed its applications in Computer-Aided designing of bioactive compounds with special reference to designing of carbonic anhydrase inhibitors, lipophilicity, toxicity, tadpole narcosis, bio-concentration factor, diuretic activity and carcinogenic activity of aromatic hydrocarbons and heterocycles etc.
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Cite this article as:
Khadikar V. Padmakar, Diudea V. Mircea, Singh Jyoti, John E. Peter, Shrivastva Anjalee, Singh Shalini, Karmarkar Sneha, Lakhwani Meenakshi and Thakur Purnima, Use of PI Index in Computer-Aided Designing of Bioactive Compounds, Current Bioactive Compounds 2006; 2 (1) . https://dx.doi.org/10.2174/1573407210602010019
DOI https://dx.doi.org/10.2174/1573407210602010019 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
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