AP-1 a Target for Cancer Prevention

Title: AP-1 a Target for Cancer Prevention

Volume: 7 Issue: 4

Author(s): Connie P. Matthews, Nancy H. Colburn and Matthew R. Young

Affiliation:

Keywords: Fra-1, Jun, TAM67, tumor promotion, invasion, inflammation

Abstract: The transcription factor activator protein 1 (AP-1) plays a pivotal role in tumorigenesis. AP-1 activity is increased in multiple human tumor types. Inhibitors of AP-1 have been shown to block tumor promotion, transformation, progression and invasion. Chronic inflammation and tumor development are linked. AP-1 may act, in part, by perpetuating the inflammatory signal. AP-1 is a recognized molecular target of many antioxidant and anti-inflammatory chemopreventive compounds. This review focuses on the AP-1 family proteins as targets for chemoprevention.

Cite this article as:

Matthews P. Connie, Colburn H. Nancy and Young R. Matthew, AP-1 a Target for Cancer Prevention, Current Cancer Drug Targets 2007; 7 (4) . https://dx.doi.org/10.2174/156800907780809723