Abstract
The catalytic C-C bond activation by rhodium complexes has found a wide application in organic synthesis. The course of the reaction is usually controlled by the proper ligand environment enabling processes that are otherwise not feasible under classical conditions of organic chemistry. The C-C bond activation can be achieved by the release of ringstrain in cycloalkanes (e.g. compounds possessing three- and four-membered rings), in case of non-strained C-C bonds it could be directed by a neighboring functionality (e.g. carbonyl group), or through initial C-H activation (e.g. aldehyde decarbonylation). Many of these processes have been implemented in syntheses of various natural compounds. The use of chiral ligands has recently enabled to carry many of these reactions in an enantioselective manner.
Keywords: Rhodium, C-C bond cleavage, Catalysis, Synthesis, σ-orbitals, C–Rh bond, C–C bond activation, norbornadiene, monodentate, cyclopropyl group
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
67