Abstract
Reactive oxygen species (ROS) are involved in cardiovascular diseases and, in particular, in myocardial ischemia and reperfusion. Although the restoration of blood flow is essential for salvation of ischemic heart, reperfusion elicits itself additional tissue damages. This condition has been defined as myocardial-reperfusion injury. ROS have been firstly studied for their deleterious role during reperfusion, including protein oxidation, DNA strand breaks, lipids peroxydation or opening of mitochondrial permeability transition pore, that are all potentially harmful for the cell survival. Indeed, ROS are massively generated at the onset of reperfusion, contributing to the post-ischemic oxidative stress and mitochondrial dysfunction and ultimately leading to cardiomyocyte death. Animal studies using antioxidant treatments have shown beneficial and encouraging effects in myocardial ischemia-reperfusion. However, univocal interpretations of the results from clinical trials remain uncertain and controversial. Recently, another role of ROS had been highlighted. Multiple evidences had shown that ROS act as essential mediators of cardioprotection, mainly during pre- and post-conditioning. Thus, free radicals in myocardial ischemia reperfusion injury may be not considered just as detrimental but also as protective molecules. This review summarizes recent findings about this dual role of ROS in myocardial ischemia-reperfusion injury
Keywords: Cardioprotection, Cardiovascular diseases, Ischemia-reperfusion, Myocardial infarction, Oxidative stress
Current Signal Transduction Therapy
Title:Reactive Oxygen-Induced Cardiac Intracellular Pathways During Ischemia and Reperfusion
Volume: 7 Issue: 2
Author(s): Vincent Braunersreuther, François Mach and Fabrizio Montecucco
Affiliation:
Keywords: Cardioprotection, Cardiovascular diseases, Ischemia-reperfusion, Myocardial infarction, Oxidative stress
Abstract: Reactive oxygen species (ROS) are involved in cardiovascular diseases and, in particular, in myocardial ischemia and reperfusion. Although the restoration of blood flow is essential for salvation of ischemic heart, reperfusion elicits itself additional tissue damages. This condition has been defined as myocardial-reperfusion injury. ROS have been firstly studied for their deleterious role during reperfusion, including protein oxidation, DNA strand breaks, lipids peroxydation or opening of mitochondrial permeability transition pore, that are all potentially harmful for the cell survival. Indeed, ROS are massively generated at the onset of reperfusion, contributing to the post-ischemic oxidative stress and mitochondrial dysfunction and ultimately leading to cardiomyocyte death. Animal studies using antioxidant treatments have shown beneficial and encouraging effects in myocardial ischemia-reperfusion. However, univocal interpretations of the results from clinical trials remain uncertain and controversial. Recently, another role of ROS had been highlighted. Multiple evidences had shown that ROS act as essential mediators of cardioprotection, mainly during pre- and post-conditioning. Thus, free radicals in myocardial ischemia reperfusion injury may be not considered just as detrimental but also as protective molecules. This review summarizes recent findings about this dual role of ROS in myocardial ischemia-reperfusion injury
Export Options
About this article
Cite this article as:
Braunersreuther Vincent, Mach François and Montecucco Fabrizio, Reactive Oxygen-Induced Cardiac Intracellular Pathways During Ischemia and Reperfusion, Current Signal Transduction Therapy 2012; 7 (2) . https://dx.doi.org/10.2174/157436212800376726
DOI https://dx.doi.org/10.2174/157436212800376726 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
![](/images/wayfinder.jpg)
- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Mean Platelet Volume During Ischemic Stroke is a Potential Pro-inflammatory Biomarker in the Acute Phase and During Neurorehabilitation Not Directly Linked to Clinical Outcome
Current Neurovascular Research An Approach to Whole-Genome Identification of IRES Elements
Current Genomics Intracoronary Injection of Drugs to Treat No – Reflow Phenomenon and Microcirculatory Dysfunction
Cardiovascular & Hematological Agents in Medicinal Chemistry Mechanisms of the Beneficial Actions of Ischemic Preconditioning on Subcellular Remodeling in Ischemic-Reperfused Heart
Current Cardiology Reviews NHE-1: A Promising Target for Novel Anti-cancer Therapeutics
Current Pharmaceutical Design Editorial (Thematic Issue: The Coronary Collateral Circulation – Past, Present and Future)
Current Cardiology Reviews Cardiac and Pulmonary Manifestations in the Antiphospholipid Syndrome
Current Rheumatology Reviews Cardiovascular Complications of HIV Infection and Treatment
Cardiovascular & Hematological Agents in Medicinal Chemistry Assessment and Clinical Relevance of Non-Fasting and Postprandial Triglycerides: An Expert Panel Statement
Current Vascular Pharmacology Raxofelast, (±)5-(Acetyloxy)-2,3-dihydro-4,6,7-trimethyl-2-benzofuranacetic Acid: A New Antioxidant to Modulate the Inflammatory Response During Ischemia-Reperfusion Injury and Impaired Wound Healing
Mini-Reviews in Medicinal Chemistry The Role of Nitric Oxide on Endothelial Function
Current Vascular Pharmacology Antithrombotic Therapy in Cardiac Embolism
Current Cardiology Reviews Vascular Endothelial Function Change in Elderly Chinese Patients with Obstructive Sleep Apnea and its Association with Coronary Heart Disease
Vascular Disease Prevention (Discontinued) Epidemiology and Adverse Consequences of Hookah/Waterpipe Use: A Systematic Review
Cardiovascular & Hematological Agents in Medicinal Chemistry Hematoma Expansion: Clinical and Molecular Predictors and Corresponding Pharmacological Treatment
Current Drug Targets Challenges and Perspectives of Antiplatelet Therapy in Patients with Diabetes Mellitus and Coronary Artery Disease
Current Pharmaceutical Design Phytochemicals as Prototypes for Pharmaceutical Leads Towards Drug Development Against Diabetic Cardiomyopathy
Current Pharmaceutical Design The Epidemiology of Cardiovascular Disease in Adults with Type 1 Diabetes
Current Diabetes Reviews In Search for the Troponin of the Kidney
Current Medicinal Chemistry Endocrine Therapies and QTc Prolongation
Current Drug Safety