A Novel Practical Synthesis of Pazopanib: An Anticancer Drug

Title:A Novel Practical Synthesis of Pazopanib: An Anticancer Drug

Volume: 9 Issue: 4

Author(s): YiCheng Mei, BaoWei Yang, Wei Chen, DanDan Huang, Ying Li, Xin Deng, BaoMing Liu, JingJie Wang, Hai Qian, WenLong Huang

Affiliation:

Keywords: Anticancer drug, pazopanib, regioselective methylation, synthesis, trimethyl orthoformate, vasculature, dichloropyrimidine, chloride, methylene

Abstract: This paper reports a novel approach to synthesize pazopanib. In our synthetic route, the potently mutagenic alkylating agents such as dimethyl sulfate and methyl iodide are avoided. A novel regioselective methylation of the 2- position of 3-methyl-6-nitro-1H-indazole was reported. This novel route is one step shorter than the previously reported route.

Cite this article as:

YiCheng Mei, BaoWei Yang, Wei Chen, DanDan Huang, Ying Li, Xin Deng, BaoMing Liu, JingJie Wang, Hai Qian, WenLong Huang , A Novel Practical Synthesis of Pazopanib: An Anticancer Drug, Letters in Organic Chemistry 2012; 9 (4) . https://dx.doi.org/10.2174/157017812800233714