Abstract
The properties of heparin, a key anticoagulant, are reviewed. The important issues in heparinotherapy, i.e., reaching quick anticoagulant effect, maintaining therapeutic level of anticoagulation, heparin inhibition and non-invasive heparin formulations have been reviewed and discussed, with the focus on the role of polymeric substances in the proposed solutions.
Keywords: Heparin, anticoagulation, unfractionated heparin, low molecular weight heparin, heparin reversal, noninvasive delivery, heparinotherapy, heparin inhibition, polymeric substances, glycosaminoglycans (GAGs)
Current Pharmaceutical Design
Title:Heparin - a Key Drug in the Treatment of the Circulatory Degenerative Diseases: Controlling its Action with Polymers
Volume: 18 Issue: 18
Author(s): Krzysztof Szczubialka, Kamil Kaminski, Katarzyna Zasada, Anna Karewicz and Maria Nowakowska
Affiliation:
Keywords: Heparin, anticoagulation, unfractionated heparin, low molecular weight heparin, heparin reversal, noninvasive delivery, heparinotherapy, heparin inhibition, polymeric substances, glycosaminoglycans (GAGs)
Abstract: The properties of heparin, a key anticoagulant, are reviewed. The important issues in heparinotherapy, i.e., reaching quick anticoagulant effect, maintaining therapeutic level of anticoagulation, heparin inhibition and non-invasive heparin formulations have been reviewed and discussed, with the focus on the role of polymeric substances in the proposed solutions.
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Cite this article as:
Szczubialka Krzysztof, Kaminski Kamil, Zasada Katarzyna, Karewicz Anna and Nowakowska Maria, Heparin - a Key Drug in the Treatment of the Circulatory Degenerative Diseases: Controlling its Action with Polymers, Current Pharmaceutical Design 2012; 18 (18) . https://dx.doi.org/10.2174/138161212800492840
DOI https://dx.doi.org/10.2174/138161212800492840 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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