Abstract
During the degradation of heme by the enzyme heme oxygenase (HO), Carbon monoxide (CO) is generated. Although it is considered as a non - significant and potentially toxic waste gas of heme catabolism, CO is a key signaling molecule used to regulate different cardiovascular functions. In this review, we focus the protective roles of CO in vascular injury/disease, which may be important to explore the overall protective roles of HO-1/CO system in the pathogenesis of human vascular disease.
Keywords: Carbon monoxide, Heme oxygenase, oxidative stress, hypertension, vascular diseases
Current Pharmaceutical Biotechnology
Title:Role of Carbon Monoxide in Vascular Diseases
Volume: 13 Issue: 6
Author(s): Ignazio Barbagallo, Giuseppina Marrazzo, Alessandro Frigiola, Agata Zappala and Giovanni Li Volti
Affiliation:
Keywords: Carbon monoxide, Heme oxygenase, oxidative stress, hypertension, vascular diseases
Abstract: During the degradation of heme by the enzyme heme oxygenase (HO), Carbon monoxide (CO) is generated. Although it is considered as a non - significant and potentially toxic waste gas of heme catabolism, CO is a key signaling molecule used to regulate different cardiovascular functions. In this review, we focus the protective roles of CO in vascular injury/disease, which may be important to explore the overall protective roles of HO-1/CO system in the pathogenesis of human vascular disease.
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Cite this article as:
Barbagallo Ignazio, Marrazzo Giuseppina, Frigiola Alessandro, Zappala Agata and Li Volti Giovanni, Role of Carbon Monoxide in Vascular Diseases, Current Pharmaceutical Biotechnology 2012; 13 (6) . https://dx.doi.org/10.2174/138920112800399086
DOI https://dx.doi.org/10.2174/138920112800399086 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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