Abstract
RuCl3·3H2O was found to be an effective catalyst for one-pot reactions of benzylic alcoholes with indoles affording the corresponding bis(indolyl)methanes under air atmosphere at room temperature in moderate to excellent yields. It is noteworthy that the RuCl3·3H2O system displayed a preference for the primary versus secondary benzylic group of a benzylic diol in intramolecular competition experiments.
Keywords: Benzylic alcohol, Bis(indolyl)methane, RuCl3·3H2O, Indole.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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