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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Immune Cell-derived Vesicles: Modulators and Mediators of Inflammation

Author(s): Esther N.M. Nolte-‘t Hoen and Marca H.M. Wauben

Volume 18, Issue 16, 2012

Page: [2357 - 2368] Pages: 12

DOI: 10.2174/138161212800166013

Price: $65

Abstract

Most cell types can release vesicles. Cell-derived vesicles are increasingly recognized as an evolutionary wide-spread mechanism of intercellular communication. The paracrine and long range activity of vesicles and their regulated cargo-composition endows these vesicles with regulatory properties beyond that of the parental cell. The release and biogenesis of cell-derived vesicles is a dynamic and tightly controlled process. In the past years it has become clear that these vesicles exert a plethora of biological effects. This has sparked the intense interest in these vesicles in relation to (patho)physiological processes. This review focuses on the role of cell-derived vesicles in inflammation, with emphasis on the immune modulating capacity of immune cell-derived vesicles. The biological activity of different leukocyte-derived vesicles is compared, and potential explanations for the strong biological effects exhibited by vesicles are provided. The role of cell-derived vesicles in inflammatory processes is discussed by speculating how these vesicles can contribute to allergic inflammation.

Keywords: Exosome, microvesicle, microparticle, membrane vesicle, ectosome, allergy, immune regulation, immune cells


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