Abstract
Respiratory syncytial virus (RSV) is the major respiratory pathogen of infants and children worldwide, with no effective treatment or vaccine available. Steady progress has been made in understanding the respiratory syncytial virus lifecycle and the consequences of infection, but some areas of RSV still remain poorly understood. Although many of the interactions between virus proteins that are required for efficient RSV assembly have been elucidated, many questions still remain regarding viral assembly, as well as the mechanisms of RSV budding. This review will summarise the current understanding of RSV assembly, including the various interactions between virus proteins and the involvement of cellular factors with a view to identifying possible attenuation and/or drug targets within the assembly pathway.
Keywords: RSV assembly, envelope glycoprotein complex, nucleocapsid complex, RSV budding
Infectious Disorders - Drug Targets
Title:Protein-Protein Interactions in RSV Assembly: Potential Targets for Attenuating RSV Strains
Volume: 12 Issue: 2
Author(s): Reena Ghildyal, David A. Jans, Philip G. Bardin and John Mills
Affiliation:
Keywords: RSV assembly, envelope glycoprotein complex, nucleocapsid complex, RSV budding
Abstract: Respiratory syncytial virus (RSV) is the major respiratory pathogen of infants and children worldwide, with no effective treatment or vaccine available. Steady progress has been made in understanding the respiratory syncytial virus lifecycle and the consequences of infection, but some areas of RSV still remain poorly understood. Although many of the interactions between virus proteins that are required for efficient RSV assembly have been elucidated, many questions still remain regarding viral assembly, as well as the mechanisms of RSV budding. This review will summarise the current understanding of RSV assembly, including the various interactions between virus proteins and the involvement of cellular factors with a view to identifying possible attenuation and/or drug targets within the assembly pathway.
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Cite this article as:
Ghildyal Reena, A. Jans David, G. Bardin Philip and Mills John, Protein-Protein Interactions in RSV Assembly: Potential Targets for Attenuating RSV Strains, Infectious Disorders - Drug Targets 2012; 12 (2) . https://dx.doi.org/10.2174/187152612800100125
DOI https://dx.doi.org/10.2174/187152612800100125 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
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