Abstract
The present article deals with the synthesis, antimicrobial and antimycobacterial activities of a novel series of N-(5-(2-(5-(arylidene)-4-oxo-3-phenylthiazolidin-2-ylidene)hydrazinecarbonyl)-4-methylthiazol-2-yl)benzamides (6a-o). The structures of these compounds have been elucidated by spectra (IR, 1H NMR, 13C NMR, mass spectra). All the synthesized compounds are screened for in vitro antibacterial activity against Gram-positive (Staphylococcus aureus, Streptococcus pyogenes) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria. These compounds are also tested for their inhibitory action against three strains of fungi (Candida albicans, Aspergillus niger, Aspergillus clavatus). Same synthesized compounds are also tested for their in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv.
Keywords: Antibacterial activity, antifungal activity, antimycobacterial activity, knoevengel reaction, MIC, thiazole, thiazolidinone
Anti-Infective Agents
Title:Synthesis and Characterization of Some New Thiazole based Thiazolidinone Derivatives as Potent Antimicrobial and Antimycobacterial Agents
Volume: 10 Issue: 2
Author(s): N. C. Desai, K. M. Rajpara, V. V. Joshi, H. V. Vaghani and H. M. Satodiya
Affiliation:
Keywords: Antibacterial activity, antifungal activity, antimycobacterial activity, knoevengel reaction, MIC, thiazole, thiazolidinone
Abstract: The present article deals with the synthesis, antimicrobial and antimycobacterial activities of a novel series of N-(5-(2-(5-(arylidene)-4-oxo-3-phenylthiazolidin-2-ylidene)hydrazinecarbonyl)-4-methylthiazol-2-yl)benzamides (6a-o). The structures of these compounds have been elucidated by spectra (IR, 1H NMR, 13C NMR, mass spectra). All the synthesized compounds are screened for in vitro antibacterial activity against Gram-positive (Staphylococcus aureus, Streptococcus pyogenes) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria. These compounds are also tested for their inhibitory action against three strains of fungi (Candida albicans, Aspergillus niger, Aspergillus clavatus). Same synthesized compounds are also tested for their in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv.
Export Options
About this article
Cite this article as:
C. Desai N., M. Rajpara K., V. Joshi V., V. Vaghani H. and M. Satodiya H., Synthesis and Characterization of Some New Thiazole based Thiazolidinone Derivatives as Potent Antimicrobial and Antimycobacterial Agents, Anti-Infective Agents 2012; 10 (2) . https://dx.doi.org/10.2174/2211362611208020075
DOI https://dx.doi.org/10.2174/2211362611208020075 |
Print ISSN 2211-3525 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-3533 |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
CRISPR/Cas9 Genome Editing Tool: A Promising Tool for Therapeutic Applications on Respiratory Diseases
Current Gene Therapy Efficacy and Cardiovascular Safety of Metformin
Current Drug Safety Voltammetric and Impidimetric Detection of Anticancer Drug Mitomycin C and DNA Interaction by Using Carbon Nanotubes Modified Electrodes
Current Bionanotechnology (Discontinued) Neuroprotective Appraisal of Methanolic Extract of Flowers of Nerium oleander in a Non Classical Rat Model of Alzheimer Disease
The Natural Products Journal Advances in Synthesis and Medicinal Applications of Compounds Derived from Phthalimide
Current Organic Synthesis Meet Our Editor-in-Chief
Current Chinese Chemistry The Progress of Selective Fluorescent Chemosensors by Boronic Acid
Current Medicinal Chemistry Important Aspects of Post-Prandial Antidiabetic Drug, Acarbose
Current Topics in Medicinal Chemistry Rational Basis for the Use of Bergamot Essential Oil in Complementary Medicine to Treat Chronic Pain
Mini-Reviews in Medicinal Chemistry Flavonoid Derivatives As Potent Tyrosinase Inhibitors - A Survey of Recent Findings Between 2008-2013
Current Topics in Medicinal Chemistry Bioactive Polyphenols from Healthy Diets and Forest Biomass
Current Nutrition & Food Science Exploring the Phosphoproteome with Mass Spectrometry
Mini-Reviews in Medicinal Chemistry An Integrated Platform for Bio-Analysis and Drug Delivery
Current Pharmaceutical Biotechnology High-throughput Screening Identifies Small Molecule Inhibitors of Molecular Chaperones
Current Pharmaceutical Design Aliphatic and Aromatic Oxidations, Epoxidation and S-Oxidation of Prodrugs that Yield Active Drug Metabolites
Current Medicinal Chemistry Chemical Structure and Surface Modification of Dendritic Nanomaterials Tailored for Therapeutic and Diagnostic Applications
Current Topics in Medicinal Chemistry Human Saliva Metabolome for Oral Lichen Planus Biomarker Identification
Recent Patents on Anti-Cancer Drug Discovery Proteomics of Human Pulmonary Surfactant Proteins
Current Proteomics Anti-EGFR-mAb and 5-Fluorouracil Conjugated Polymeric Nanoparticles for Colorectal Cancer
Recent Patents on Anti-Cancer Drug Discovery Molecular Biomarkers in Schizophrenia – Implications for Clinical Practice
Current Psychiatry Reviews