Synthesis and Antimicrobial Activity of Some Novel Schiffs Bases of 4-Methyl-2-Thiazolamine

M.      Rudrapal; B.      De; N.      Devanna

doi:10.2174/2211362611201010072

Abstract

In the present study, some novel Schiffs bases of 4-methyl-2-thiazolamine were synthesized by condensation of 2-amino-4-methylthiazole with different substituted aromatic aldehydes. Structures of newer Schiffs bases were established on the basis of IR, 1HNMR, Mass spectral data and elemental analyses. All the synthesized compounds were obtained in good yields and high purity. The antimicrobial activity of the synthesized compounds was preliminarily evaluated by paper disc diffusion technique. The minimum inhibitory concentrations (MIC) of the compounds were also determined by tube dilution method. All the compounds showed antibacterial activity at the tested dose against four different strains of Gram positive and Gram negative bacteria but were considerably less when compared to the reference standard drug ciprofloxacin. Among the synthesized compounds 2a, 2b, 2c, 2d exhibited to some extent better activity against all the tested strains. The antifungal activity was also found to be considerably less than that of the standard drug ketoconazole for all the synthesized compounds.

Keywords: 4-Methyl-2-thiazolamine, Schiff's bases, Antimicrobial activity, Microbial infection, TLC