Abstract
After the completion of the human genome sequence, international efforts have been directed to the characterization of the genomes of human-associated resident microbes. The Human Microbiome Project was launched in 2007 with the aim of sequencing the resident microbiota from different sites of the human body. In this paper, we introduce the Human Microbiome Project, the role of the human microbiome in health and disease, and the implications of the microbiome variations in personalized medicine and in pharmacomicrobiomics, which we define as the effect of microbiome variations on drug disposition, action, and toxicity.
Keywords: Metagenomics, microbiome, microbiota, next-generation sequencing, pharmacogenomics, personalized medicine
Current Pharmacogenomics and Personalized Medicine
Title: The Human Microbiome Project, Personalized Medicine and the Birth of Pharmacomicrobiomics
Volume: 8 Issue: 3
Author(s): Mariam Reyad Rizkallah, Rama Saad and Ramy Karam Aziz
Affiliation:
Keywords: Metagenomics, microbiome, microbiota, next-generation sequencing, pharmacogenomics, personalized medicine
Abstract: After the completion of the human genome sequence, international efforts have been directed to the characterization of the genomes of human-associated resident microbes. The Human Microbiome Project was launched in 2007 with the aim of sequencing the resident microbiota from different sites of the human body. In this paper, we introduce the Human Microbiome Project, the role of the human microbiome in health and disease, and the implications of the microbiome variations in personalized medicine and in pharmacomicrobiomics, which we define as the effect of microbiome variations on drug disposition, action, and toxicity.
Export Options
About this article
Cite this article as:
Rizkallah Reyad Mariam, Saad Rama and Aziz Karam Ramy, The Human Microbiome Project, Personalized Medicine and the Birth of Pharmacomicrobiomics, Current Pharmacogenomics and Personalized Medicine 2010; 8 (3) . https://dx.doi.org/10.2174/187569210792246326
DOI https://dx.doi.org/10.2174/187569210792246326 |
Print ISSN 1875-6921 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6913 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cerebrovascular Complications After Heart Transplantation
Current Cardiology Reviews Heart Failure in Sub-Saharan Africa
Current Cardiology Reviews Infection, Infectious Agents and Vascular Disease
Reviews on Recent Clinical Trials Molecular Dynamics Simulations of Novel Potential Inhibitors for Penicillin Binding Protein 2B of the Resistant 5204 Strain of Streptococcus pneumoniae
Current Computer-Aided Drug Design Cardiovascular Disease in Antiphospholipid Syndrome
Current Vascular Pharmacology Perceval Sutureless Valve – are Sutureless Valves Here?
Current Cardiology Reviews Antibiotic Dosage Regimens in Respiratory Tract Infections in the Pharmacokinetic/Pharmacodynamic Era
Current Respiratory Medicine Reviews Current Research on Opioid Receptor Function
Current Drug Targets Microbial Biofilms: Impact on the Pathogenesis of Periodontitis, Cystic Fibrosis, Chronic Wounds and Medical Device-Related Infections
Current Topics in Medicinal Chemistry Magnetite Nanoshuttles for Fighting Staphylococcus aureus Infections: A Recent Review
Current Topics in Medicinal Chemistry Central Nervous System Vasculitis: Still More Questions than Answers
Current Neuropharmacology Activation of Macrophages: Establishing a Role for Polysaccharides in Drug Delivery Strategies Envisaging Antibacterial Therapy
Current Pharmaceutical Design The Cancer Related Thrombotic Tendency in Sepsis
Current Drug Targets Drainage of Cerebral Abscesses Prior to Valve Replacement in Stable Patients with Acute Left-Sided Infective Endocarditis
CNS & Neurological Disorders - Drug Targets Chlorophylls and their Derivatives Used in Food Industry and Medicine
Mini-Reviews in Medicinal Chemistry Surgical Treatment of Pulmonary Embolism and Chronic Thromboembolic Pulmonary Hypertension
Current Pharmaceutical Design Dissecting the Therapeutic Potency of Antimicrobial Peptides Against Microbial Biofilms
Current Protein & Peptide Science Small Molecule Approaches Toward the Non-Microbicidal Modulation of Bacterial Biofilm Growth and Maintenance
Anti-Infective Agents in Medicinal Chemistry Isolation of <i>Morganella Morganii</i> and <i>Providencia</i> Species from Clinical Samples in a Tertiary Care Hospital in North India
Infectious Disorders - Drug Targets Effect of Silver Nanoparticles (AgNPs) on <i>Candida albicans, Candida dubliniensis</i> and <i>Candida guilliermondii</i>
Current Drug Therapy