Synthetic Methodologies for the Preparation of Epothilones and Analogs

Inacio      Luduvico; Mireille   L.   Hyaric; Mauro   V.   De Almeida; Adilson   D.   Da Silva

doi:10.2174/157019306775474194

Abstract

Epothilones are natural products present in the myxobacterium Sorangium cellulossum strain 90. Due to their antitumoral activity, they are good candidates for the treatment of various forms of cancer, and epothilones B and D and some synthetic analogs are actually under advanced clinical trials. This review describes the synthesis of epothilones A and B and some of their analogs.

Keywords: Epothilone, antitumor compounds, total synthesis

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Mini-Reviews in Organic Chemistry

Title: Synthetic Methodologies for the Preparation of Epothilones and Analogs

Volume: 3 Issue: 1

Author(s): Inacio Luduvico, Mireille L. Hyaric, Mauro V. De Almeida and Adilson D. Da Silva

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Keywords: Epothilone, antitumor compounds, total synthesis

Abstract: Epothilones are natural products present in the myxobacterium Sorangium cellulossum strain 90. Due to their antitumoral activity, they are good candidates for the treatment of various forms of cancer, and epothilones B and D and some synthetic analogs are actually under advanced clinical trials. This review describes the synthesis of epothilones A and B and some of their analogs.

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Luduvico Inacio, Hyaric L. Mireille, De Almeida V. Mauro and Da Silva D. Adilson, Synthetic Methodologies for the Preparation of Epothilones and Analogs, Mini-Reviews in Organic Chemistry 2006; 3 (1) . https://dx.doi.org/10.2174/157019306775474194