Abstract
Since the beginning of the AIDS pandemic, and following the discovery of the human immunodeficiency virus (HIV) as the etiological agent of the disease, it was clear that the virus gains access to the human host predominantly through the mucosal tissue after sexual exposure. As a consequence, the female genital tract (vaginal and cervical), as well as the rectal, penile, and oral mucosae have been extensively studied over the last thirty years towards a better understanding of - and to develop strategies to prevent - sexual HIV transmission. This review seeks to describe the biology of the events leading to HIV infection through the human mucosa and introduce some of the approaches attempted to prevent the sexual transmission of HIV.
Keywords: HIV, sexual transmission, oral transmission, microbicides, AIDS, CD4+, vaginal, microbial invasion, epithelial, exposure
Current HIV Research
Title: Mucosal Transmission of Human Immunodeficiency Virus
Volume: 10 Issue: 1
Author(s): Denis M. Tebit, Nicaise Ndembi, Aaron Weinberg and Miguel E. Quinones-Mateu
Affiliation:
Keywords: HIV, sexual transmission, oral transmission, microbicides, AIDS, CD4+, vaginal, microbial invasion, epithelial, exposure
Abstract: Since the beginning of the AIDS pandemic, and following the discovery of the human immunodeficiency virus (HIV) as the etiological agent of the disease, it was clear that the virus gains access to the human host predominantly through the mucosal tissue after sexual exposure. As a consequence, the female genital tract (vaginal and cervical), as well as the rectal, penile, and oral mucosae have been extensively studied over the last thirty years towards a better understanding of - and to develop strategies to prevent - sexual HIV transmission. This review seeks to describe the biology of the events leading to HIV infection through the human mucosa and introduce some of the approaches attempted to prevent the sexual transmission of HIV.
Export Options
About this article
Cite this article as:
M. Tebit Denis, Ndembi Nicaise, Weinberg Aaron and E. Quinones-Mateu Miguel, Mucosal Transmission of Human Immunodeficiency Virus, Current HIV Research 2012; 10 (1) . https://dx.doi.org/10.2174/157016212799304689
DOI https://dx.doi.org/10.2174/157016212799304689 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Brainstem Neuropeptides and Vagal Protection of the Gastric Mucosal Against Injury: Role of Prostaglandins, Nitric Oxide and Calcitonin-Gene Related Peptide in Capsaicin Afferents
Current Medicinal Chemistry Atorvastatin Inhibits Advanced Glycation End Products (AGE)-Induced C-Reactive Expression in Hepatoma Cells by Suppressing Reactive Oxygen Species Generation
Vascular Disease Prevention (Discontinued) The Role of Intracrine Androgen Metabolism, Androgen Receptor and Apoptosis in the Survival and Recurrence of Prostate Cancer During Androgen Deprivation Therapy
Current Drug Targets The Protective Role of Heme Oxygenase-1 in Cerebral Ischemia
Central Nervous System Agents in Medicinal Chemistry Asthma, Allergy and Chemokines
Current Drug Targets The Activated Endocannabinoid System in Atherosclerosis: Driving Force or Protective Mechanism?
Current Drug Targets Is Small Really Beautiful? Nanosensors and Low Abundance Biomarkers for Personalized Medicine
Current Pharmacogenomics and Personalized Medicine Animal Models of Narcolepsy
CNS & Neurological Disorders - Drug Targets Genetic Variants in Diseases of the Extrapyramidal System
Current Genomics Good at Heart: Preserving Cardiac Metabolism during aging
Current Diabetes Reviews Avian Flu; Pathogenesis and Therapy
Anti-Infective Agents The Treatment of Wrist Osteoarthritis, SLAC Wrist Grade 3-4
Current Rheumatology Reviews Pathophysiology of Chronic Obstructive Pulmonary Disease
Current Respiratory Medicine Reviews Role of Thymidine Phosphorylase in Biomodulation of Fluoropyrimidines
Current Pharmaceutical Biotechnology Implication of Possible Therapies Targeted for the Tachykinergic System with the Biology of Neurokinin Receptors and Emerging Related Proteins
Recent Patents on CNS Drug Discovery (Discontinued) Molecular Biological Roles of Ursolic Acid in the Treatment of Human Diseases
Current Bioactive Compounds Novel 4- Aryl-2(1H)-phthalazinone Derivatives as Cyclooxygenase-2 Inhibitors: Synthesis, Molecular Modeling Study and Evaluation as Promising Anti-inflammatory Agents
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Drug Acyl Glucuronides: Reactivity and Analytical Implication
Current Pharmaceutical Analysis The Possible Involvement of Glycogen Synthase Kinase-3 (GSK-3) in Diabetes, Cancer and Central Nervous System Diseases
Current Pharmaceutical Design Signal Transduction Therapy of Diabetic Vascular Complication
Current Signal Transduction Therapy