Abstract
Schwann cells are critically important for tissue repair, axonal regrowth and remyelination following injury to peripheral nerves. The absence of Schwann cells or an equivalent cell type in the central nervous system (CNS) may limit the regeneration capacity of the CNS. Mesenchymal stem cells (MSCs) have therefore been investigated for their potential to be induced to develop a Schwann cell phenotype. The methods for derivation of Schwann cell-like cells from MSCs and the benefits and limitations of each of these methods are presented in this review. Issues related to instability of the derived Schwann cell phenotype, apoptosis of derived cells in transplants, and the inability to predict with confidence how the cells will behave after transplantation are discussed. Finally, we suggest the need for further elucidation of the biology of Schwann cell differentiation and the signals for their derivation from MSC, in order to resolve these obstacles and to enable transplantation of MSC-derived Schwann cells as a therapeutic strategy in CNS injury.
Keywords: Mesenchymal stem cells, Schwann cells, spinal cord injury, two-step induction, stem cell co-culture, peripheral nervous system, central nervous system, embryonic stem cells, induced pluripotent stem cells, neural stem cels, olfactory ensheathing cells
CNS & Neurological Disorders - Drug Targets
Title: Derivation of Clinically Applicable Schwann Cells from Bone Marrow Stromal Cells for Neural Repair and Regeneration
Volume: 10 Issue: 4
Author(s): Sa Cai, Graham K.H. Shea, Alex Y.P. Tsui, Ying-Shing Chan and Daisy K.Y. Shum
Affiliation:
Keywords: Mesenchymal stem cells, Schwann cells, spinal cord injury, two-step induction, stem cell co-culture, peripheral nervous system, central nervous system, embryonic stem cells, induced pluripotent stem cells, neural stem cels, olfactory ensheathing cells
Abstract: Schwann cells are critically important for tissue repair, axonal regrowth and remyelination following injury to peripheral nerves. The absence of Schwann cells or an equivalent cell type in the central nervous system (CNS) may limit the regeneration capacity of the CNS. Mesenchymal stem cells (MSCs) have therefore been investigated for their potential to be induced to develop a Schwann cell phenotype. The methods for derivation of Schwann cell-like cells from MSCs and the benefits and limitations of each of these methods are presented in this review. Issues related to instability of the derived Schwann cell phenotype, apoptosis of derived cells in transplants, and the inability to predict with confidence how the cells will behave after transplantation are discussed. Finally, we suggest the need for further elucidation of the biology of Schwann cell differentiation and the signals for their derivation from MSC, in order to resolve these obstacles and to enable transplantation of MSC-derived Schwann cells as a therapeutic strategy in CNS injury.
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Cite this article as:
Cai Sa, K.H. Shea Graham, Y.P. Tsui Alex, Chan Ying-Shing and K.Y. Shum Daisy, Derivation of Clinically Applicable Schwann Cells from Bone Marrow Stromal Cells for Neural Repair and Regeneration, CNS & Neurological Disorders - Drug Targets 2011; 10 (4) . https://dx.doi.org/10.2174/187152711795563930
DOI https://dx.doi.org/10.2174/187152711795563930 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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