Parenteral Drug Delivery: A Review

Neha      Gulati; Himanshu      Gupta

doi:10.2174/187221111795471391

Abstract

The parenteral route of administration is the most effective route for the delivery of the active pharmaceutical substances with narrow therapeutic index, poor bioavailability especially for those drugs, prescribed to unconscious patients. To maintain a therapeutic effective concentration of the drug, it requires frequent injections which ultimately lead to patient discomfort. In parenteral drug delivery, major progress has been done in the field of formulation technologies so as to provide a targeted and sustained release of drug in predictable manner. The present article reviews recent patents and major advancements in parenteral drug delivery systems along with general introduction. This article also deals with importance of novel systems in drug delivery to overcome the problems associated with conventional parenteral drug delivery systems.

Keywords: in situ Depot forming systems, liposomes, nanodispersions, niosomes, parenteral drug delivery, polymeric nanoparticles, solid lipid nanoparticles, Parenteral Formulations, Nanosuspensions, Polymeric Particulates