Abstract
The endothelium has an important regulatory role in the maintenance of vascular homeostasis, vascular tone, blood flow, and in preserving a non-thrombogenic blood-tissue interface. Injury to the vascular wall with subsequent endothelial dysfunction alters these important regulatory functions leading to a state of abnormal endothelial function. In this paper, we review the pathophysiology of endothelial dysfunction and how this disorder is common to the development of erectile dysfunction and of pulmonary arterial hypertension. Current medical therapies for these two disorders are discussed followed by a review of the preclinical studies involving currently available strategies for gene and stem cell therapy and their potential for the clinical treatment of these two disorders of endothelial dysfunction.
Keywords: Endothelium, vascular/pp, impotence/et, male, risk factors, pulmonary hypertension/dt, cardiovascular diseases/dt, gene therapy/mt, adult, aging/pa
Current Gene Therapy
Title: Gene and Stem Cell Therapy in the Treatment of Erectile Dysfunction and Pulmonary Hypertension; Potential Treatments for the Common Problem of Endothelial Dysfunction
Volume: 7 Issue: 2
Author(s): Bobby D. Nossaman, Serap Gur and Philip J. Kadowitz
Affiliation:
Keywords: Endothelium, vascular/pp, impotence/et, male, risk factors, pulmonary hypertension/dt, cardiovascular diseases/dt, gene therapy/mt, adult, aging/pa
Abstract: The endothelium has an important regulatory role in the maintenance of vascular homeostasis, vascular tone, blood flow, and in preserving a non-thrombogenic blood-tissue interface. Injury to the vascular wall with subsequent endothelial dysfunction alters these important regulatory functions leading to a state of abnormal endothelial function. In this paper, we review the pathophysiology of endothelial dysfunction and how this disorder is common to the development of erectile dysfunction and of pulmonary arterial hypertension. Current medical therapies for these two disorders are discussed followed by a review of the preclinical studies involving currently available strategies for gene and stem cell therapy and their potential for the clinical treatment of these two disorders of endothelial dysfunction.
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Nossaman D. Bobby, Gur Serap and Kadowitz J. Philip, Gene and Stem Cell Therapy in the Treatment of Erectile Dysfunction and Pulmonary Hypertension; Potential Treatments for the Common Problem of Endothelial Dysfunction, Current Gene Therapy 2007; 7 (2) . https://dx.doi.org/10.2174/156652307780363161
DOI https://dx.doi.org/10.2174/156652307780363161 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
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