Toxicokinetic Interaction Between Quetiapine and Antiretroviral Therapy Following Quetiapine Overdose

Title: Toxicokinetic Interaction Between Quetiapine and Antiretroviral Therapy Following Quetiapine Overdose

Volume: 4 Issue: 1

Author(s): P. Hantson, V. Di Fazio and P. Wallemacq

Affiliation:

Keywords: Quetiapine, overdose, half life, antiretroviral therapy, CYP3A4

Abstract: A 47-year-old woman ingested an overdose of 8000 mg quetiapine. The treatment had been initiated 3 weeks before. The current medications were lamuvidine, ritonavir, atazanavir and tenofovir for an HIV infection. The patient presented a deep coma and sustained hypotension as main complications. The toxicokinetic data revealed a markedly prolonged elimination half-life for quetiapine (62.4 hours) and the relationship with antiretroviral therapy is discussed.

Cite this article as:

Hantson P., Fazio Di V. and Wallemacq P., Toxicokinetic Interaction Between Quetiapine and Antiretroviral Therapy Following Quetiapine Overdose, Drug Metabolism Letters 2010; 4 (1) . https://dx.doi.org/10.2174/187231210790980426