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Current Proteomics

Editor-in-Chief

ISSN (Print): 1570-1646
ISSN (Online): 1875-6247

Proteins as Networks: A Mesoscopic Approach Using Haemoglobin Molecule as Case Study

Author(s): Alessandro Giuliani, Luisa Di Paola and Roberto Setola

Volume 6, Issue 4, 2009

Page: [235 - 245] Pages: 11

DOI: 10.2174/157016409789973743

Price: $65

Abstract

Protein structures allow for a straightforward representation in terms of graph theory being the nodes the aminoacid residues and the edges the scoring of a spatial contact between the node pairs. Such a representation allows for a direct use in the realm of protein science of the vast repertoire of graph invariants developed in the analysis of complex networks. In this work we give a general overview of the protein as networks paradigm with a special emphasis on haemoglobin where the most important features of protein systems like allostery, protein-protein contacts and differential effect of mutations were demonstrated to be amenable to a graph theory oriented translation.


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