Abstract
Protein structures allow for a straightforward representation in terms of graph theory being the nodes the aminoacid residues and the edges the scoring of a spatial contact between the node pairs. Such a representation allows for a direct use in the realm of protein science of the vast repertoire of graph invariants developed in the analysis of complex networks. In this work we give a general overview of the protein as networks paradigm with a special emphasis on haemoglobin where the most important features of protein systems like allostery, protein-protein contacts and differential effect of mutations were demonstrated to be amenable to a graph theory oriented translation.
Current Proteomics
Title: Proteins as Networks: A Mesoscopic Approach Using Haemoglobin Molecule as Case Study
Volume: 6 Issue: 4
Author(s): Alessandro Giuliani, Luisa Di Paola and Roberto Setola
Affiliation:
Abstract: Protein structures allow for a straightforward representation in terms of graph theory being the nodes the aminoacid residues and the edges the scoring of a spatial contact between the node pairs. Such a representation allows for a direct use in the realm of protein science of the vast repertoire of graph invariants developed in the analysis of complex networks. In this work we give a general overview of the protein as networks paradigm with a special emphasis on haemoglobin where the most important features of protein systems like allostery, protein-protein contacts and differential effect of mutations were demonstrated to be amenable to a graph theory oriented translation.
Export Options
About this article
Cite this article as:
Giuliani Alessandro, Di Paola Luisa and Setola Roberto, Proteins as Networks: A Mesoscopic Approach Using Haemoglobin Molecule as Case Study, Current Proteomics 2009; 6 (4) . https://dx.doi.org/10.2174/157016409789973743
DOI https://dx.doi.org/10.2174/157016409789973743 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers