Abstract
A survey of the chemo-enzymatic methodology for the preparation of nucleosides of biological importance is presented. The emphasis is made on the enzymatic transglycosylation and glycosylation employing the nucleoside phosphorylases and N-deoxyribosyltransferases. Application of the whole cells as biocatalysts as well as purified enzymes from wild-type bacteria and recombinant enzymes is considered.
Keywords: N-Deoxyribosyltransferases, nucleoside deoxyribosyltransferase, Nucleoside Phosphorylases, Escherichia coli, cytidine deaminase (CDase)
Current Organic Chemistry
Title: Biotechnology of Nucleic Acid Constituents - State of the Art and Perspectives
Volume: 11 Issue: 4
Author(s): Igor A. Mikhailopulo
Affiliation:
Keywords: N-Deoxyribosyltransferases, nucleoside deoxyribosyltransferase, Nucleoside Phosphorylases, Escherichia coli, cytidine deaminase (CDase)
Abstract: A survey of the chemo-enzymatic methodology for the preparation of nucleosides of biological importance is presented. The emphasis is made on the enzymatic transglycosylation and glycosylation employing the nucleoside phosphorylases and N-deoxyribosyltransferases. Application of the whole cells as biocatalysts as well as purified enzymes from wild-type bacteria and recombinant enzymes is considered.
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Cite this article as:
Mikhailopulo A. Igor, Biotechnology of Nucleic Acid Constituents - State of the Art and Perspectives, Current Organic Chemistry 2007; 11 (4) . https://dx.doi.org/10.2174/138527207780059330
DOI https://dx.doi.org/10.2174/138527207780059330 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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