HIV-1 Vpr: A Novel Role in Regulating RNA Splicing

Xianfeng      Zhang; Yoko      Aida

doi:10.2174/157016209787581517

Abstract

Pre-mRNA splicing is a critical step in gene expression for metazoans. Several viral proteins regulate the splicing of pre-mRNAs through complex interactions with the host cell RNA splicing machinery. Here, we focus on a novel function of HIV-1 Vpr, which selectively inhibits cellular and viral pre-mRNA splicing via interactions with components of the spliceosome complex. This review discusses our current knowledge of how RNA splicing regulation is accomplished by Vpr-host factor interactions.

Keywords: HIV-1Vpr, splicing inhibition, cellular pre-mRNA, HIV-1 genome, spliceosome

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Current HIV Research

Title: HIV-1 Vpr: A Novel Role in Regulating RNA Splicing

Volume: 7 Issue: 2

Author(s): Xianfeng Zhang and Yoko Aida

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Keywords: HIV-1Vpr, splicing inhibition, cellular pre-mRNA, HIV-1 genome, spliceosome

Abstract: Pre-mRNA splicing is a critical step in gene expression for metazoans. Several viral proteins regulate the splicing of pre-mRNAs through complex interactions with the host cell RNA splicing machinery. Here, we focus on a novel function of HIV-1 Vpr, which selectively inhibits cellular and viral pre-mRNA splicing via interactions with components of the spliceosome complex. This review discusses our current knowledge of how RNA splicing regulation is accomplished by Vpr-host factor interactions.

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Zhang Xianfeng and Aida Yoko, HIV-1 Vpr: A Novel Role in Regulating RNA Splicing, Current HIV Research 2009; 7 (2) . https://dx.doi.org/10.2174/157016209787581517