Abstract
The mammalian target of rapamycin (mTOR) plays an important role in cell growth. Dysfunction of mTOR has been linked to many human diseases, such as cancers, obesity, diabetes, cardiovascular diseases and neurological disorders. Currently, the mTOR inhibitor rapamycin and its analogs have been vigorously evaluated and developed as anticancer drugs. Here, we will review the most recent patents and patent applications relating to mTOR pathway. Moreover, we will discuss the patents and patent applications on the treatment of mTOR-associated metabolic diseases and cancers.
Keywords: mTOR, mTORC1, mTORC2, rapamycin, Akt/PKB, S6K, 4EBP1, TSC1/TSC2, Rheb, cancer
Recent Patents on DNA & Gene Sequences
Title: Recent Patents and Patent Applications Relating to mTOR Pathway
Volume: 3 Issue: 1
Author(s): Xiangyu Liu and Zhenyu Yue
Affiliation:
Keywords: mTOR, mTORC1, mTORC2, rapamycin, Akt/PKB, S6K, 4EBP1, TSC1/TSC2, Rheb, cancer
Abstract: The mammalian target of rapamycin (mTOR) plays an important role in cell growth. Dysfunction of mTOR has been linked to many human diseases, such as cancers, obesity, diabetes, cardiovascular diseases and neurological disorders. Currently, the mTOR inhibitor rapamycin and its analogs have been vigorously evaluated and developed as anticancer drugs. Here, we will review the most recent patents and patent applications relating to mTOR pathway. Moreover, we will discuss the patents and patent applications on the treatment of mTOR-associated metabolic diseases and cancers.
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Cite this article as:
Liu Xiangyu and Yue Zhenyu, Recent Patents and Patent Applications Relating to mTOR Pathway, Recent Patents on DNA & Gene Sequences 2009; 3 (1) . https://dx.doi.org/10.2174/187221509787236192
DOI https://dx.doi.org/10.2174/187221509787236192 |
Print ISSN 1872-2156 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3431 |
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