Identification of Four Urea Adducts of Andrographolide in Humans

Title: Identification of Four Urea Adducts of Andrographolide in Humans

Volume: 2 Issue: 4

Author(s): Liang Cui, Wan Chan, Feng Qiu, Zongwei Cai and Xinsheng Yao

Affiliation:

Keywords: Andrographolide, metabolites, urea adducts, human urine, NMR, HRSI-MS

Abstract: Andrographolide is a component of a famous traditional Chinese herbal medicine Andrographis paniculate (Burm) Nees. In this study, the metabolites of andrographolide in human urine after oral administration were investigated. Four urea adducts were isolated by chromatography methods and identified by high-resolution mass spectra, 1 D and 2D NMR spectroscopy.

Cite this article as:

Cui Liang, Chan Wan, Qiu Feng, Cai Zongwei and Yao Xinsheng, Identification of Four Urea Adducts of Andrographolide in Humans, Drug Metabolism Letters 2008; 2 (4) . https://dx.doi.org/10.2174/187231208786734148