Abstract
Only rarely in modern medicine is an entirely new class of drug developed. Recently, a number of drugs that act as leukotriene modifiers (LTMs) have been licensed for use in the treatment of asthma. Airway obstruction in asthma has two key components-bronchoconstriction of airway smooth muscle and airway inflammation. Although a number of mediators are involved in this process, it has been demonstrated that leukotrienes can precipitate both. Leukotrienes are formed in eosinophils, mast cells and neutrophils. LTMs have been shown to attenuate bronchial hyper-reactivity and reduce chemotaxis of inflammatory cells in the asthmatic airway. This article reviews the data from clinical trials of LTMs, discusses their role in asthma therapy and postulates on use in other common respiratory diseases.
Keywords: Leukotriene Modifying Drugs, Asthma, Bronchoconstriction, Leukotrienes, Airway Inflammation, Cystic Fibrosis
Current Drug Targets - Inflammation & Allergy
Title: The Use of Leukotriene Modifying Drugs in Asthma and Other Respiratory Diseases
Volume: 1 Issue: 3
Author(s): J. A. Corless and M. Paracha
Affiliation:
Keywords: Leukotriene Modifying Drugs, Asthma, Bronchoconstriction, Leukotrienes, Airway Inflammation, Cystic Fibrosis
Abstract: Only rarely in modern medicine is an entirely new class of drug developed. Recently, a number of drugs that act as leukotriene modifiers (LTMs) have been licensed for use in the treatment of asthma. Airway obstruction in asthma has two key components-bronchoconstriction of airway smooth muscle and airway inflammation. Although a number of mediators are involved in this process, it has been demonstrated that leukotrienes can precipitate both. Leukotrienes are formed in eosinophils, mast cells and neutrophils. LTMs have been shown to attenuate bronchial hyper-reactivity and reduce chemotaxis of inflammatory cells in the asthmatic airway. This article reviews the data from clinical trials of LTMs, discusses their role in asthma therapy and postulates on use in other common respiratory diseases.
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Cite this article as:
Corless A. J. and Paracha M., The Use of Leukotriene Modifying Drugs in Asthma and Other Respiratory Diseases, Current Drug Targets - Inflammation & Allergy 2002; 1 (3) . https://dx.doi.org/10.2174/1568010023344643
DOI https://dx.doi.org/10.2174/1568010023344643 |
Print ISSN 1568-010X |
Publisher Name Bentham Science Publisher |
Online ISSN 1568-010X |
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