Serotonin Type-4 (5-HT4) Receptors as Therapeutic Targets: 5-HT4 Receptor Antagonists

Title: Serotonin Type-4 (5-HT4) Receptors as Therapeutic Targets: 5-HT4 Receptor Antagonists

Volume: 3 Issue: 1

Author(s): Henri Mattes and Hans-Juergen Pfannkuche

Affiliation:

Keywords: 5-ht4 receptor, 5-ht4 receptor antagonist, serotonin antagonist

Abstract: Characterization of 5-HT 4 receptors started in the late eighties following the important finding that the potent 5-HT3 receptor antagonist, tropisetron, could act as a competitive antagonist at the newly discovered 5-HT4 receptor. During recent years several pharmaceutical companies claimed that their 5-HT4 antagonists might be useful for the treatment and / or prophylaxis of cardiovascular, CNS and gastrointestinal disorders. This paper reviews the development of 5-HT4 receptor antagonists from experimental tools towards potential therapeutic agents.

Cite this article as:

Mattes Henri and Pfannkuche Hans-Juergen, Serotonin Type-4 (5-HT4) Receptors as Therapeutic Targets: 5-HT4 Receptor Antagonists, Current Medicinal Chemistry - Central Nervous System Agents 2003; 3 (1) . https://dx.doi.org/10.2174/1568015033357742