The Chaperoning and Assistance Roles of the HIV-1 Nucleocapsid Protein in Proviral DNA Synthesis and Maintenance

Title: The Chaperoning and Assistance Roles of the HIV-1 Nucleocapsid Protein in Proviral DNA Synthesis and Maintenance

Volume: 2 Issue: 1

Author(s): Carole Bampi, Sandrine Jacquenet, Daniela Lener, Didier Decimo and Jean- Luc Darlix

Affiliation:

Keywords: hiv, nucleocapsid protein, nucleic acid chaperone, reverse transcription, genetic variability, proviral dna maintenance

Abstract: In the following three sections we will briefly review the seminal roles of the HIV-1 nucleocapsid protein NCp7 in the fate of the HIV-1 full length RNA from genomic RNA in a dimeric form to the proviral DNA. Emphasis will be given to the mechanisms of NC-directed assistance to the genomic RNA and reverse transcriptase in the course of proviral DNA synthesis and to DNA integrity at the end of the polymerization process, and to the NC-assisted repair and recombination reactions fueling the viability and variability of the virus.

Cite this article as:

Bampi Carole, Jacquenet Sandrine, Lener Daniela, Decimo Didier and Darlix Luc Jean-, The Chaperoning and Assistance Roles of the HIV-1 Nucleocapsid Protein in Proviral DNA Synthesis and Maintenance, Current HIV Research 2004; 2 (1) . https://dx.doi.org/10.2174/1570162043485022