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Current Drug Discovery Technologies

Editor-in-Chief

ISSN (Print): 1570-1638
ISSN (Online): 1875-6220

The Oxazolomycins: A Structurally Novel Class of Bioactive Compounds

Author(s): Mark G. Moloney, Paul C. Trippier, Muhammad Yaqoob and Zhaoyang Wang

Volume 1, Issue 3, 2004

Page: [181 - 199] Pages: 19

DOI: 10.2174/1570163043334974

Price: $65

Abstract

Oxazolomycin, first isolated in 1985, is a novel bioactive compound, exhibiting potent antiviral, antibacterial and cytotoxic activity, and is now known to be the parent of a wider class of compounds. The broad-spectrum activity of oxazolomycin has been attributed to its protonophoric properties. This review outlines the isolation, structural determination, biosynthesis, bioactivity, biological mode of action and synthesis of all members of this compound class. Significantly, the oxazolomycins appear to offer not only a completely novel chemotype as a bioactive lead structure, but also a chemotype, which also exhibits an unusual biological mode of action.

Keywords: Oxazolomycins, chemotype, protonophoric


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