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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

NF-κB Inhibitors for the Treatment of Inflammatory Diseases and Cancer

Author(s): Marco A. Calzado, Susanne Bacher and M. Lienhard Schmitz

Volume 14, Issue 3, 2007

Page: [367 - 376] Pages: 10

DOI: 10.2174/092986707779941113

Price: $65

Abstract

The NF-κB/Rel signaling system is a paradigm for gene activation in response to inflammatory and menacing stimuli. Given the growing body of evidence showing an important involvement of NF-κB for the onset of autoimmune diseases and different types of cancer, NF-κB is an important drug target for the adjuvant therapy of these diseases. Great efforts have been made for the development of highly specific NF-κB inhibitors, some of them being currently tested in phase II clinical trials. Here we discuss recent progress in the identification of druggable components of the NF- κB signaling system and the development and potential use of novel NF-κB inhibitors.

Keywords: Inflammation, cancer, NF-κB, Inhibitor, IκB, IKK, Transcription factor

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