Abstract
Aporphinoids form an important group of plant secondary metabolites. Some of these compounds are used for a long time in traditional medicine for the treatment of various diseases, from benign syndromes to more severe illnesses. More than 500 aporphine alkaloids have been isolated from various plant families and many of these compounds display potent cytotoxic activities which may be exploited for the design of anticancer agents. Here we review the origin, biosynthesis, structure and cytotoxic properties of the prominent members of this class of compounds. Simple aporphinoids (boldine, dicentrine) as well as oxo-, pro- and dehydro-aporphines, and dimeric forms such as thalicarpine, are discussed here. Their mechanisms of action are not well known but DNA-manipulating enzymes such as polymerases and topoisomerases are among the most frequently cited targets for these benzylisoquinoline compounds. This review presents an updated view of the cytotoxic properties of the aporphinoids and their potential contribution to the development of anticancer agents.
Keywords: aporphine alkaloids, aporphinoids, anticancer agents, natural products, cytotoxicity
Current Medicinal Chemistry - Anti-Cancer Agents
Title: Cytotoxic and Antitumor Potentialities of Aporphinoid Alkaloids
Volume: 5 Issue: 2
Author(s): C. Stevigny, C. Bailly and J. Quetin-Leclercq
Affiliation:
Keywords: aporphine alkaloids, aporphinoids, anticancer agents, natural products, cytotoxicity
Abstract: Aporphinoids form an important group of plant secondary metabolites. Some of these compounds are used for a long time in traditional medicine for the treatment of various diseases, from benign syndromes to more severe illnesses. More than 500 aporphine alkaloids have been isolated from various plant families and many of these compounds display potent cytotoxic activities which may be exploited for the design of anticancer agents. Here we review the origin, biosynthesis, structure and cytotoxic properties of the prominent members of this class of compounds. Simple aporphinoids (boldine, dicentrine) as well as oxo-, pro- and dehydro-aporphines, and dimeric forms such as thalicarpine, are discussed here. Their mechanisms of action are not well known but DNA-manipulating enzymes such as polymerases and topoisomerases are among the most frequently cited targets for these benzylisoquinoline compounds. This review presents an updated view of the cytotoxic properties of the aporphinoids and their potential contribution to the development of anticancer agents.
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Cite this article as:
Stevigny C., Bailly C. and Quetin-Leclercq J., Cytotoxic and Antitumor Potentialities of Aporphinoid Alkaloids, Current Medicinal Chemistry - Anti-Cancer Agents 2005; 5 (2) . https://dx.doi.org/10.2174/1568011053174864
DOI https://dx.doi.org/10.2174/1568011053174864 |
Print ISSN 1568-0118 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5968 |
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