Abstract
Aporphinoids form an important group of plant secondary metabolites. Some of these compounds are used for a long time in traditional medicine for the treatment of various diseases, from benign syndromes to more severe illnesses. More than 500 aporphine alkaloids have been isolated from various plant families and many of these compounds display potent cytotoxic activities which may be exploited for the design of anticancer agents. Here we review the origin, biosynthesis, structure and cytotoxic properties of the prominent members of this class of compounds. Simple aporphinoids (boldine, dicentrine) as well as oxo-, pro- and dehydro-aporphines, and dimeric forms such as thalicarpine, are discussed here. Their mechanisms of action are not well known but DNA-manipulating enzymes such as polymerases and topoisomerases are among the most frequently cited targets for these benzylisoquinoline compounds. This review presents an updated view of the cytotoxic properties of the aporphinoids and their potential contribution to the development of anticancer agents.
Keywords: aporphine alkaloids, aporphinoids, anticancer agents, natural products, cytotoxicity
Current Medicinal Chemistry - Anti-Cancer Agents
Title: Cytotoxic and Antitumor Potentialities of Aporphinoid Alkaloids
Volume: 5 Issue: 2
Author(s): C. Stevigny, C. Bailly and J. Quetin-Leclercq
Affiliation:
Keywords: aporphine alkaloids, aporphinoids, anticancer agents, natural products, cytotoxicity
Abstract: Aporphinoids form an important group of plant secondary metabolites. Some of these compounds are used for a long time in traditional medicine for the treatment of various diseases, from benign syndromes to more severe illnesses. More than 500 aporphine alkaloids have been isolated from various plant families and many of these compounds display potent cytotoxic activities which may be exploited for the design of anticancer agents. Here we review the origin, biosynthesis, structure and cytotoxic properties of the prominent members of this class of compounds. Simple aporphinoids (boldine, dicentrine) as well as oxo-, pro- and dehydro-aporphines, and dimeric forms such as thalicarpine, are discussed here. Their mechanisms of action are not well known but DNA-manipulating enzymes such as polymerases and topoisomerases are among the most frequently cited targets for these benzylisoquinoline compounds. This review presents an updated view of the cytotoxic properties of the aporphinoids and their potential contribution to the development of anticancer agents.
Export Options
About this article
Cite this article as:
Stevigny C., Bailly C. and Quetin-Leclercq J., Cytotoxic and Antitumor Potentialities of Aporphinoid Alkaloids, Current Medicinal Chemistry - Anti-Cancer Agents 2005; 5 (2) . https://dx.doi.org/10.2174/1568011053174864
DOI https://dx.doi.org/10.2174/1568011053174864 |
Print ISSN 1568-0118 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5968 |
Related Articles
-
Developments of Polo-like Kinase 1 (Plk1) Inhibitors as Anti-Cancer Agents
Mini-Reviews in Medicinal Chemistry The Human Pseudoautosomal Region (PAR): Origin, Function and Future
Current Genomics Alternate Strategies of Hsp90 Modulation for the Treatment of Cancer and Other Diseases
Current Topics in Medicinal Chemistry Clinical Application of Sorafenib for Treating Hepatocellular Carcinoma and Beyond
Clinical Cancer Drugs Recent Advances in Liposomal Drug Delivery: A Review
Pharmaceutical Nanotechnology Targeting Lentiviral Vectors for Cancer Immunotherapy
Current Cancer Therapy Reviews Exopolysaccharide Produced from <i>Rhizobium</i> spp. - An Interesting Product for Industry and Environment
Current Applied Polymer Science Immune Mechanism, Aging, Season and Diseases: Modulatory Role of Melatonin
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Endothelial Chemokines in Autoimmune Disease
Current Pharmaceutical Design Nonsense-Mediated mRNA Decay: A Comparative Analysis of Different Species
Current Genomics Transforming Growth Factor-β Signaling in Motor Neuron Diseases
Current Molecular Medicine Regulation of Gene Expression by TDP-43 and FUS/TLS in Frontotemporal Lobar Degeneration
Current Alzheimer Research Cytochrome P450-Activated Prodrugs: Targeted Drug Delivery
Current Medicinal Chemistry Synthetic Peptides Derived from the C-Terminal Region of Lys49 Phospholipase A2 Homologues from Viperidae Snake Venoms: Biomimetic Activities and Potential Applications
Current Pharmaceutical Design KRAS: A Promising Therapeutic Target for Cancer Treatment
Current Topics in Medicinal Chemistry Epigenetic Targets and their Inhibitors in Cancer Therapy
Current Topics in Medicinal Chemistry Natural Products Derived from Traditional Chinese Medicine as Novel Inhibitors of the Epidermal Growth Factor Receptor
Combinatorial Chemistry & High Throughput Screening Antineoplastic Effects of PPARγ Agonists, with a Special Focus on Thyroid Cancer
Current Medicinal Chemistry Anaplastic Lymphoma Kinase as a Therapeutic Target in Anaplastic Large Cell Lymphoma, Non-Small Cell Lung Cancer and Neuroblastoma
Anti-Cancer Agents in Medicinal Chemistry Mutagenic Approaches to Modifying Gap Junction Phenotype
Current Drug Targets