AMP-Activated Protein Kinase (AMPK): Regulation of Metabolic Gene Expression

U.   S.   Varanasi

doi:10.2174/156801305774322457

Abstract

AMPK (AMP-activated protein kinase) is a serine/threonine kinase that functions as a metabolic master switch by regulating ATP consuming anabolic pathways and ATP generating catabolic pathways in response to cellular energy status. It is activated in response to stresses such as: diabetes, hypoxia, toxins, nutrient deprivation, hormones and drugs. Although most of the known functions of AMPK are due to regulation of metabolic enzyme activity in cytoplasm, a growing body of evidence suggests that AMPK also functions as major regulator of metabolic gene expression. Here I review our current understanding of how AMPK regulates gene expression at the transcriptional, mRNA stability, and protein synthesis levels.

Keywords: ampk, aicar, fkhr, hnf-a, chrebp, ppar, hur, importin a/b