Studies of Bioactivity, Conformation and Pharmacokinetic Profiles of Site-Specific PEGylated Thymosin Alpha 1 Derivatives

Title: Studies of Bioactivity, Conformation and Pharmacokinetic Profiles of Site-Specific PEGylated Thymosin Alpha 1 Derivatives

Volume: 1 Issue: 3

Author(s): Jiankun Qie, Jinbo Ma, Liangyou Wang, Xiaoyu Xu, Jianquan Zheng, Sijian Dong, Jianwei Xie, Huixian Sun, Wenxia Zhou, Chunhui Qi, Xiunan Zhao, Yongxiang Zhang and Keliang Liu

Affiliation:

Keywords: Site-specific PEGylation, thymosin alpha 1, immunoactivity

Abstract: Site-specific mono-PEGylations were performed in different conformational regions of Thymosin alpha 1 (Tα1) by introducing one cysteine residue into the chosen site and coupling with thiol-specific mPEG-MAL reagent. Results demonstrated that PEGylated sites and regions influenced the conformations and pharmacokinetic profiles of the peptide greatly with following order: α-helix, β-turn, random coil and terminals, but little on the immunoactivity.

Cite this article as:

Jiankun Qie , Jinbo Ma , Liangyou Wang , Xiaoyu Xu , Jianquan Zheng , Sijian Dong , Jianwei Xie , Huixian Sun , Wenxia Zhou , Chunhui Qi , Xiunan Zhao , Yongxiang Zhang and Keliang Liu , Studies of Bioactivity, Conformation and Pharmacokinetic Profiles of Site-Specific PEGylated Thymosin Alpha 1 Derivatives, Drug Metabolism Letters 2007; 1 (3) . https://dx.doi.org/10.2174/187231207781369780