Abstract
Glucuronidation of 5-DFCR, a metabolite of capecitabine, was confirmed in experimental models from rats whereas 5-DFCR glucuronide was detected neither in bile or liver from mice nor in livermicrosomes from human. Metabolic interactions at the level of the glucuronidation pathway between CAP and other drugs are unlikely in patients.
Keywords: Capecitabine, glucuronide, human, rat, mice, cytidine deaminase
Drug Metabolism Letters
Title: A Glucuronidation Pathway of Capecitabine Occurs in Rats but Not in Mice and Humans
Volume: 1 Issue: 2
Author(s): F. Desmoulin, C. Claparols, D. Bon, G. Larrieu, R. Martino and M. Malet-Martino
Affiliation:
Keywords: Capecitabine, glucuronide, human, rat, mice, cytidine deaminase
Abstract: Glucuronidation of 5-DFCR, a metabolite of capecitabine, was confirmed in experimental models from rats whereas 5-DFCR glucuronide was detected neither in bile or liver from mice nor in livermicrosomes from human. Metabolic interactions at the level of the glucuronidation pathway between CAP and other drugs are unlikely in patients.
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Cite this article as:
Desmoulin F., Claparols C., Bon D., Larrieu G., Martino R. and Malet-Martino M., A Glucuronidation Pathway of Capecitabine Occurs in Rats but Not in Mice and Humans, Drug Metabolism Letters 2007; 1 (2) . https://dx.doi.org/10.2174/187231207780363615
DOI https://dx.doi.org/10.2174/187231207780363615 |
Print ISSN 1872-3128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-0758 |
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