In Vitro Inhibition of Rat CYP1A1 and CYP1A2 by Piceatannol, a Hydroxylated Metabolite of trans-Resveratrol

Title: In Vitro Inhibition of Rat CYP1A1 and CYP1A2 by Piceatannol, a Hydroxylated Metabolite of trans-Resveratrol

Volume: 1 Issue: 1

Author(s): Thomas K. H. Chang, Jie Chen and Chia-Ting Yu

Affiliation:

Keywords: CYP1A1, CYP1A2, cytochrome P450, piceatannol, trans-resveratrol

Abstract: Piceatannol and its parent compound, trans-resveratrol, decreased the in vitro catalytic activity of rat CYP1A1 and CYP1A2 by mixed inhibition. trans-Resveratrol was not a mechanism-based inactivator of rat CYP1A in vitro and the administration of this compound (50 mg/kg) to rats did not affect hepatic microsomal CYP1A-mediated enzyme activity.

Cite this article as:

H. Chang K. Thomas, Chen Jie and Yu Chia-Ting, In Vitro Inhibition of Rat CYP1A1 and CYP1A2 by Piceatannol, a Hydroxylated Metabolite of trans-Resveratrol, Drug Metabolism Letters 2007; 1 (1) . https://dx.doi.org/10.2174/187231207779814337