Regioselective C-S Bond Formation Accomplished by Regioselective C-F Substitution of Polyfluoroarenes with Substituted Thiophenols

Title: Regioselective C-S Bond Formation Accomplished by Regioselective C-F Substitution of Polyfluoroarenes with Substituted Thiophenols

Volume: 9 Issue: 3

Author(s): Qizhong Zhou, Bin Zhang, Haining Gu, Aiguo Zhong, Tieqi Du, Qiong Zhou, Yuyuan Ye, Zhengneng Jin, Huajiang Jiang and Rener Chen

Affiliation:

Keywords: Polyfluorobenzene, thiophenol, SNAr, selective substution, Octafluoroanthracene, parylene, nickel, decarboxylative, thiophenols, atmosphere

Abstract: The nucleophilic aromatic substitution reaction of pentafluorobenzene, methyl 2,3,4,5-tetrafluorobenzoic acid ester and 1,2,4,5-tetrafluorobenzene with substituted thiophenols showed good regioselectivity while pentafluorobenzene gave high yields. The computational results suggest that the specificity difference between polyfluorobenzenes originates from their electronic properties.

Cite this article as:

Zhou Qizhong, Zhang Bin, Gu Haining, Zhong Aiguo, Du Tieqi, Zhou Qiong, Ye Yuyuan, Jin Zhengneng, Jiang Huajiang and Chen Rener, Regioselective C-S Bond Formation Accomplished by Regioselective C-F Substitution of Polyfluoroarenes with Substituted Thiophenols, Letters in Organic Chemistry 2012; 9 (3) . https://dx.doi.org/10.2174/157017812800167493