Synthesis of New S-alkylated-3-mercapto-1,2,4-triazole Derivatives Bearing Cyclic Amine Moiety as Potent Anticancer Agents

Title: Synthesis of New S-alkylated-3-mercapto-1,2,4-triazole Derivatives Bearing Cyclic Amine Moiety as Potent Anticancer Agents

Volume: 9 Issue: 3

Author(s): M. S.R. Murty, Kesur R. Ram, Rayudu Venkateswara Rao, J. S. Yadav, Janapala Venkateswara Rao and L. R. Velatooru

Affiliation:

Keywords: 1,2,4-Triazoles, Acid hydrazides, Piperazines, Anticancer, S-alkylated-3-mercapto-1,2,4-triazole Derivatives, Cyclic Amine Moiety, Cancer drug discovery, side-effect profile, CNS, piperazine derivatives, Cytotoxicity Studies, MTT, cytotoxicity, catalytic

Abstract: A series of 3-[3-[4-(Substituted)-1-cyclicamine]propyl]thio-5-substituted[1,2,4]triazoles (8a-j) were synthesized with good yields starting from corresponding carboxylic acids. The cytotoxicity studies of these derivatives were studied against five different human cancer cell lines. Three compounds had shown good anticancer activity. The triazole derivatives, 8i and 8j were most potent particularly against U937 and HL-60 cells. The cytotoxic potency of the compounds varied between the cell lines suggesting that a structural property of these compounds as possible determinants of their biological activity.

Cite this article as:

S.R. Murty M., R. Ram Kesur, Venkateswara Rao Rayudu, S. Yadav J., Venkateswara Rao Janapala and R. Velatooru L., Synthesis of New S-alkylated-3-mercapto-1,2,4-triazole Derivatives Bearing Cyclic Amine Moiety as Potent Anticancer Agents, Letters in Drug Design & Discovery 2012; 9 (3) . https://dx.doi.org/10.2174/157018012799129882