Abstract
Microwave assisted solid phase synthesis of imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrimidines by the treatment of polymer-bound α-bromoketone with various 2-aminopyridines or 2-aminopyrimidines was achieved. Functionalizations of the 3-positions were realized by the treatment of polymer-bound 3-iodoimidazo[1,2-a]pyridine or polymer-bound 3-iodoimidazo[1,2-a]pyrimidine with various boronic acids under Suzuki-Miyaura reaction conditions. 6- Position of polymer-bound imidazo[1,2-a]pyridine was also functionalized using Suzuki-Miyaura cross-coupling reaction
Keywords: Imidazo[1,2-a]pyridine imidazo[1,2-a]pyrimidine, microwave irradiations, solid phase synthesis, Suzuki-Miyaura cross-coupling, antiviral, antiulcer, antibacterial, antifungal, receptor ligands, calcium channel blocker
Letters in Organic Chemistry
Title: Synthesis and Functionalization of Imidazo[1,2-a]Pyridines and Imidazo[1,2-a]Pyrimidines on Solid Phase Using Suzuki-Miyaura Cross-Coupling Reactions
Volume: 9 Issue: 2
Author(s): Said El Kazzouli, Sabine Berteina-Raboin, Abderrahim Mouaddib and Gerald Guillaumet
Affiliation:
Keywords: Imidazo[1,2-a]pyridine imidazo[1,2-a]pyrimidine, microwave irradiations, solid phase synthesis, Suzuki-Miyaura cross-coupling, antiviral, antiulcer, antibacterial, antifungal, receptor ligands, calcium channel blocker
Abstract: Microwave assisted solid phase synthesis of imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrimidines by the treatment of polymer-bound α-bromoketone with various 2-aminopyridines or 2-aminopyrimidines was achieved. Functionalizations of the 3-positions were realized by the treatment of polymer-bound 3-iodoimidazo[1,2-a]pyridine or polymer-bound 3-iodoimidazo[1,2-a]pyrimidine with various boronic acids under Suzuki-Miyaura reaction conditions. 6- Position of polymer-bound imidazo[1,2-a]pyridine was also functionalized using Suzuki-Miyaura cross-coupling reaction
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El Kazzouli Said, Berteina-Raboin Sabine, Mouaddib Abderrahim and Guillaumet Gerald, Synthesis and Functionalization of Imidazo[1,2-a]Pyridines and Imidazo[1,2-a]Pyrimidines on Solid Phase Using Suzuki-Miyaura Cross-Coupling Reactions, Letters in Organic Chemistry 2012; 9 (2) . https://dx.doi.org/10.2174/157017812800221753
DOI https://dx.doi.org/10.2174/157017812800221753 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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