Abstract
Gibberellins (GAs) are tetracyclic, diterpenoid plant hormones, essential for many developmental processes in higher plants. Plants perceive GA through a nuclear-localized GA receptor, GA INSENSITIVE DWARF1 (GID1). From sequence similarity, it is suggested that GID1 evolved from a hormone-sensitive lipase (HSL), and recent x-ray crystallography of the GA-GID1 complex has given insights into how GID1 recognizes GA. Analyses of the GA signaling pathway in several plant species further suggest that the GID1-mediated GA signaling pathway emerged in the vascular plant lineage and since then regulation of GA recognition specificity seems to have been fine tuned to strictly regulate the on – off GA signal.
Keywords: DELLA protein, gibberellin (GA), GA INSENSITIVE DWARF1 (GID1), hormone-sensitive lipase (HSL), Selaginella moellendorffii, rice, epoxidation, crystallography, Arabidopsis
Protein & Peptide Letters
Title: Molecular Determinants that Convert Hormone Sensitive Lipase into Gibberellin Receptor
Volume: 19 Issue: 2
Author(s): Ko Hirano, Koichiro Aya, Makoto Matsuoka and Miyako Ueguchi-Tanaka
Affiliation:
Keywords: DELLA protein, gibberellin (GA), GA INSENSITIVE DWARF1 (GID1), hormone-sensitive lipase (HSL), Selaginella moellendorffii, rice, epoxidation, crystallography, Arabidopsis
Abstract: Gibberellins (GAs) are tetracyclic, diterpenoid plant hormones, essential for many developmental processes in higher plants. Plants perceive GA through a nuclear-localized GA receptor, GA INSENSITIVE DWARF1 (GID1). From sequence similarity, it is suggested that GID1 evolved from a hormone-sensitive lipase (HSL), and recent x-ray crystallography of the GA-GID1 complex has given insights into how GID1 recognizes GA. Analyses of the GA signaling pathway in several plant species further suggest that the GID1-mediated GA signaling pathway emerged in the vascular plant lineage and since then regulation of GA recognition specificity seems to have been fine tuned to strictly regulate the on – off GA signal.
Export Options
About this article
Cite this article as:
Hirano Ko, Aya Koichiro, Matsuoka Makoto and Ueguchi-Tanaka Miyako, Molecular Determinants that Convert Hormone Sensitive Lipase into Gibberellin Receptor, Protein & Peptide Letters 2012; 19 (2) . https://dx.doi.org/10.2174/092986612799080248
DOI https://dx.doi.org/10.2174/092986612799080248 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
IP6 (Inositol Hexaphosphate) as a Signaling Molecule
Current Signal Transduction Therapy Prospective Role of Polyphenolic Compounds in the Treatment of Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Using Pharmacogenomic Tumor Profiling to Identify Biomarkers of 5-fluorouracil Response in Colorectal Cancer
Current Pharmacogenomics Green Tea, A Medicinal Food with Promising Neurological Benefits
Current Neuropharmacology Angiogenic Properties of Primary Cells Intended at Bone Regeneration: A Comparison to Differentiated Cells Using the CAM Assay
Current Angiogenesis (Discontinued) Advances in Molecular Therapeutic Approaches to Patients with Malignant Gliomas
Current Signal Transduction Therapy Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review
Current Pharmaceutical Design Synthesis and Anti-Proliferative Evaluations of New Heterocyclic Derivatives Using 5,6,8,9-Tetrahydropyrazolo[5,1-b]quinazolin-7(3H)-one Derivatives Derived from Cyclohexa-1,4-dione
Anti-Cancer Agents in Medicinal Chemistry Discovery and Hit to Lead Optimization of Novel Combretastatin A-4 Analogues: Dependence of C-Linker Length and Hybridization
Anti-Cancer Agents in Medicinal Chemistry A Theoretical Investigation on the Pleiotropic Effects of Statins as p38 MAP Kinase Ligands
Letters in Drug Design & Discovery Novel Drug Targets in Malaria Parasite with Potential to Yield Antimalarial Drugs with Long Useful Therapeutic Lives
Current Pharmaceutical Design Prodrugs in Genetic Chemoradiotherapy
Current Pharmaceutical Design Indoles - Gut Bacteria Metabolites of Tryptophan with Pharmacotherapeutic Potential
Current Drug Metabolism Mechanisms of Enhanced Vasoconstriction in the Mouse Model of Atherosclerosis: the Beneficial Effects of Sildenafil
Current Pharmaceutical Biotechnology Bioactive Compounds for Effective Management of Drug-Resistant Tuberculosis
Current Bioactive Compounds Microcirculation in Sepsis: New Perspectives
Current Vascular Pharmacology Cyclodextrin-based Polymeric Nanoparticles as Efficient Carriers for Anticancer Drugs
Current Pharmaceutical Biotechnology Neurodegenerative Pathways in Alzheimer’s Disease: A Review
Current Neuropharmacology Chemical and Pharmacological Significance of Natural Guanidines from Marine Invertebrates
Mini-Reviews in Medicinal Chemistry Earthworms as a Source of Bioactive Molecules
Current Bioactive Compounds