Enzyme Promiscuity in the Hormone-sensitive Lipase Family of Proteins

Title: Enzyme Promiscuity in the Hormone-sensitive Lipase Family of Proteins

Volume: 19 Issue: 2

Author(s): Manco Giuseppe, Merone Luigia, Porzio Elena, Feng Yan and Mandrich Luigi

Affiliation:

Keywords: Promiscuity, α/β hydrolase fold, hormone-sensitive lipase family, biotechnological, conformations, cytochrome P450s, substrate, carboxylesterases, detoxification, ligands

Abstract: The number of enzymes endowed with the capacity to catalyse other reactions than the main, physiological one, a feature that has been called promiscuity, is increasing at a fast pace. Promiscuity is a highly pervasive phenomenon that is present at each level of life complexity. For enzymes, promiscuity encompasses interesting aspects related to their physiological role, evolution and biotechnological applications. Herein, at first we will describe some general aspects of enzyme promiscuity and then we will report some examples from the α/β hydrolase superfamily of proteins, with particular emphasis to the hormone-sensitive lipase family.

Cite this article as:

Giuseppe Manco, Luigia Merone, Elena Porzio, Yan Feng and Luigi Mandrich, Enzyme Promiscuity in the Hormone-sensitive Lipase Family of Proteins, Protein & Peptide Letters 2012; 19 (2) . https://dx.doi.org/10.2174/092986612799080400