Efficient Synthesis of β-Acetamido Ketones Catalyzed by Cobalt Sulfate Heptahydrate Under Ultrasound Irradiation

Title: Efficient Synthesis of β-Acetamido Ketones Catalyzed by Cobalt Sulfate Heptahydrate Under Ultrasound Irradiation

Volume: 9 Issue: 1

Author(s): Bao-Hua Chen, Ji-Tai Li, Guo-Feng Chen and Ya-Li Song

Affiliation:

Keywords: β-Acetamido ketones, cobalt, sulfate, heptahydrate, condensation, synthesis, ultrasound irradiation, MCRs, multi-component reaction, Dakin-West reaction, aromatic aldehyde, cobalt sulfate heptahydrate

Abstract: Ultrasound-promoted synthesis of β-acetamido ketones catalyzed by cobalt sulfate heptahydrate via one-pot multi-component reaction coupling of aromatic aldehyde, acetophenone and acetyl chloride in acetonitrile was carried out in excellent yields at 25-28 °C, providing an efficient synthesis of these compounds. The use of ultrasound increased the rate of reactions compared with reactions under reflux condition.

Cite this article as:

Chen Bao-Hua, Li Ji-Tai, Chen Guo-Feng and Song Ya-Li, Efficient Synthesis of β-Acetamido Ketones Catalyzed by Cobalt Sulfate Heptahydrate Under Ultrasound Irradiation, Letters in Organic Chemistry 2012; 9 (1) . https://dx.doi.org/10.2174/157017812799304088