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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis of Optically Active β-Aryloxy Alcohols and β-Arylthiol Alcohols via Asymmetric Transfer Hydrogenation Reaction

Author(s): Zhou Xu, Wei Yin, Nan Wu, Jingjing Shi, Ting Liu, Yu Wan and Hui Wu

Volume 8, Issue 10, 2011

Page: [737 - 742] Pages: 6

DOI: 10.2174/157017811799304197

Price: $65

Abstract

A series of optically active β-aryloxy alcohols and β-arylthiol alcohols were synthesized directly by asymmetric transfer hydrogenation of the corresponding β-carbonyl ethers or β-carbonyl sulfides in excellent yields (up to 99%) and excellent enantioselectivity (up to 100% ee) under mild reaction conditions.

Keywords: Asymmetric transfer hydrogenation, β-aryloxy alcohols, β-arylthiol alcohols, β-ketosulfide, β-ketoether, esters, hydrogen, ketones, phenylethanone, sulfides


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