Discovery of 5,6-Dihydro-indolo[1,2-a]quinoxaline Derivatives as New HIV-1 Inhibitors In Vitro

Title: Discovery of 5,6-Dihydro-indolo[1,2-a]quinoxaline Derivatives as New HIV-1 Inhibitors In Vitro

Volume: 9 Issue: 1

Author(s): Ling-Ling Fan, Ning Huang, Rui-Ge Yang, Shu-Zhen He, Liu-Meng Yang, Hui Xu and Yong-Tang Zheng

Affiliation:

Keywords: 5,6-Dihydro-indolo[1,2-a]quinoxaline, Acquired immunodeficiency syndrome, Human immunodeficiency virus-1, Inhibitor, AIDS, quinoxaline, HIV-1, Syncytia Assay, MTT-based Cytotoxicity Assay, TCID50, calf serum, Anti-HIV-1 Activity Assay, HIV-1 IIIB, Reed and Muench method

Abstract: In continuation of our program to find compounds with potent anti-human immunodeficiency virus type 1 (HIV-1) activities, seventeen 5,6-dihydro-indolo[1,2-a]quinoxaline derivatives (1-17) were preliminarily evaluated as HIV-1 inhibitors in vitro. Among all the derivatives, especially compounds 10 and 17 showed the most potent anti-HIV-1 activities with EC50 values of 2.42 and 3.39 μg/mL, and TI values of 63.76 and 53.60, respectively.

Cite this article as:

Fan Ling-Ling, Huang Ning, Yang Rui-Ge, He Shu-Zhen, Yang Liu-Meng, Xu Hui and Zheng Yong-Tang, Discovery of 5,6-Dihydro-indolo[1,2-a]quinoxaline Derivatives as New HIV-1 Inhibitors In Vitro, Letters in Drug Design & Discovery 2012; 9 (1) . https://dx.doi.org/10.2174/157018012798193026