Abstract
Over the past four decades, the search for improved platinum drugs based on the classical platinum(II)- diam(m)ine pharmacophore has yielded only a handful of successful candidates. New methodologies centred on platinum( IV) complexes, with better stability and expanded coordination spheres, offer the possibility of overcoming limitations inherent to platinum(II) drugs. In this review, novel strategies of targeting and killing cancer cells using platinum( IV) constructs are discussed. These approaches exploit the unique electrochemical characteristics and structural attributes of platinum(IV) complexes as a means of developing anticancer prodrugs that can target and selectively destroy cancer cells. Anticancer platinum(IV) prodrugs represent promising new strategies as targeted chemotherapeutic agents in the ongoing battle against cancer.
Keywords: Cisplatin, anticancer prodrugs, platinum drugs, activation by reduction, targeted delivery, targeting and killing cancer cells, platinum(IV) constructs, electrochemical characteristics and, structural attributes of platinum(IV) complexes, Anticancer platinum(IV) prodrugs, targeted chemotherapeutic agents, potent antitumour agent, colorectal, non-small cell lung and genitourinary cancers
Current Topics in Medicinal Chemistry
Title: Anticancer Platinum (IV) Prodrugs with Novel Modes of Activity
Volume: 11 Issue: 21
Author(s): Chee Fei Chin, Daniel Yuan Qiang Wong, Ramasamy Jothibasu and Wee Han Ang
Affiliation:
Keywords: Cisplatin, anticancer prodrugs, platinum drugs, activation by reduction, targeted delivery, targeting and killing cancer cells, platinum(IV) constructs, electrochemical characteristics and, structural attributes of platinum(IV) complexes, Anticancer platinum(IV) prodrugs, targeted chemotherapeutic agents, potent antitumour agent, colorectal, non-small cell lung and genitourinary cancers
Abstract: Over the past four decades, the search for improved platinum drugs based on the classical platinum(II)- diam(m)ine pharmacophore has yielded only a handful of successful candidates. New methodologies centred on platinum( IV) complexes, with better stability and expanded coordination spheres, offer the possibility of overcoming limitations inherent to platinum(II) drugs. In this review, novel strategies of targeting and killing cancer cells using platinum( IV) constructs are discussed. These approaches exploit the unique electrochemical characteristics and structural attributes of platinum(IV) complexes as a means of developing anticancer prodrugs that can target and selectively destroy cancer cells. Anticancer platinum(IV) prodrugs represent promising new strategies as targeted chemotherapeutic agents in the ongoing battle against cancer.
Export Options
About this article
Cite this article as:
Fei Chin Chee, Yuan Qiang Wong Daniel, Jothibasu Ramasamy and Han Ang Wee, Anticancer Platinum (IV) Prodrugs with Novel Modes of Activity, Current Topics in Medicinal Chemistry 2011; 11 (21) . https://dx.doi.org/10.2174/156802611798040778
DOI https://dx.doi.org/10.2174/156802611798040778 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Medicinal Chemistry Advancement in Life-Threatening Diseases
The current issue will highlight concise reports that specify ground-breaking insights, including the novel discovery of drug targets and their action mechanism or drugs of novel classes. These are projected to encourage medicinal chemistry future efforts to address the most challenging medical needs. The current issue highlights further efforts to ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Geriatric Evaluation of Oncological Elderly Patients
Anti-Cancer Agents in Medicinal Chemistry Editorial (Mini-Thematic Issue: Morphological and Molecular Backgrounds for Personalized Therapies in Genitourinary Cancers)
Current Drug Targets Clinical Utility of Combined 18F-Fluoro-2-deoxyglucose Positron Emission Tomography – Computed Tomography in the Evaluation of Gastrointestinal Malignancies
Current Medical Imaging Management of the Menopausal Disturbances and Oxidative Stress
Current Pharmaceutical Design Antisense Treatment in Human Prostate Cancer and Melanoma
Current Cancer Drug Targets Cancer Stem Cells in Prostate Cancer Chemoresistance
Current Cancer Drug Targets Natural Alkaloids and Diabetes Mellitus: A Review
Endocrine, Metabolic & Immune Disorders - Drug Targets Ligands and Therapeutic Perspectives of Adenosine A2A Receptors
Current Pharmaceutical Design PET in Anti-Cancer Drug Development and Therapy
Recent Patents on Anti-Cancer Drug Discovery A New Frontier in the Treatment of Cancer: NK-1 Receptor Antagonists
Current Medicinal Chemistry Discovering Therapeutic Protein Targets for Bladder Cancer Using Proteomic Data Analysis
Current Molecular Pharmacology Bisphosphonates in Lung Cancer: Can They Provide Benefits Beyond Prevention of Skeletal Morbidity?
Anti-Cancer Agents in Medicinal Chemistry Update on Hsp90 Inhibitors in Clinical Trial
Current Topics in Medicinal Chemistry Interventional Radiology Procedures: Current Issues in Patient Doses and Image Quality Optimization
Current Medical Imaging Sonic Hedgehog, the Penis and Erectile Dysfunction: A Review of Sonic Hedgehog Signaling in the Penis
Current Pharmaceutical Design Inflammation and Anemia
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Prognostic and Predictive Biomarkers in Cancer
Current Cancer Drug Targets Pharmacotherapy of Sickle Cell Disease in Children
Current Pharmaceutical Design Advances in the Knowledge and Clinical Applications of Lactic Acid Bacteria as Probiotics in the Urogenital Tract
Current Women`s Health Reviews Transdermal Oxandrolone: Ex Vivo Percutaneous Absorption Study
Current Drug Delivery