Titanocene Dichloride as an Efficient Catalyst for One-Pot Synthesis of α-Aminophosphonates

Title: Titanocene Dichloride as an Efficient Catalyst for One-Pot Synthesis of α-Aminophosphonates

Volume: 8 Issue: 9

Author(s): Hong-Ying Niu, Hui-Juan Li, Jian-Ping Li, Yu Huang, Run-Ze Mao, De-Yang Li, Gui-Rong Qu and Hai-Ming Guo

Affiliation:

Keywords: α-Aminophosphonates, multi-component reaction, titanocene dichloride, Aminophosphonates, titanocene, dichloride, multi-component reaction., antitumor agents, serine hydrolases, peptidomimetics, pharmacogenetical agents, enzyme, inhibitors

Abstract: Commercially available titanocene dichloride was firstly used as an extremely efficient catalyst for a three component one-pot reaction of an amine, an aldehyde (ketone), and a dialkyl phosphite to form α-aminophosphonates under solvent-free conditions at ambient temperature in good to high yields, providing a green, rapid and convenient method for the synthesis of α-aminophosphonates.

Cite this article as:

Niu Hong-Ying, Li Hui-Juan, Li Jian-Ping, Huang Yu, Mao Run-Ze, Li De-Yang, Qu Gui-Rong and Guo Hai-Ming, Titanocene Dichloride as an Efficient Catalyst for One-Pot Synthesis of α-Aminophosphonates, Letters in Organic Chemistry 2011; 8 (9) . https://dx.doi.org/10.2174/157017811799304359