Solvent-Free Microwave-Assisted Synthesis of Substituted Pyridines Using NH4OAc as Nitrogen Source

Title: Solvent-Free Microwave-Assisted Synthesis of Substituted Pyridines Using NH4OAc as Nitrogen Source

Volume: 8 Issue: 9

Author(s): Jorge Trilleras, Pedro De La Torre, Dency J. Pacheco, Jairo Quiroga, Manuel Nogueras and Justo Cobo

Affiliation:

Keywords: Chalcone, 1,5-dicarbonyl compounds, cyclocondensation, microwave, NH4OAc, pyridines, solvent-free procedure, heterocyclic, antifungal, antibacterial

Abstract: New 1,5-dicarbonyl compounds were prepared, as versatile precursors to pyridine derivatives, by a tandem Claisen-Schmidt condensation/ Michael addition reaction, that is condensation between 5-chloro-3-methyl-1-phenyl-1Hpyrazole- 4-carbaldehyde and acetophenones, and the formed adduct then reacts with a second molecule of acetophenone. The preparation of substituted pyridines was achieved using NH4OAc as nitrogen source under solvent-free microwave irradiation.

Cite this article as:

Trilleras Jorge, De La Torre Pedro, J. Pacheco Dency, Quiroga Jairo, Nogueras Manuel and Cobo Justo, Solvent-Free Microwave-Assisted Synthesis of Substituted Pyridines Using NH4OAc as Nitrogen Source, Letters in Organic Chemistry 2011; 8 (9) . https://dx.doi.org/10.2174/157017811799304296