A Simple and Efficient Method for Trifluoroacetylation of Arylamines Using Trifluoroacetic Acid and Triphosgene

Ki-Jong      Han; Misoo      Kim

doi:10.2174/157017811797249317

Abstract

A simple and efficient one-pot procedure for trifluoroacetylation of arylamines using trifluoroacetic acid and triphosgene is reported. A mixed trifluoroacetic anhydride generated in situ reacts with a variety of arylamines to give the corresponding trifluroacetamides in high yields.

Keywords: Trifluoroacetylation, trifluoroacetamides, trifluoroacetic acid, arylamines, triphosgene, N-trifluoroacetylimidazole, N-(trifluoroacetoxy)succinimide, benzotriazole, poly-phosphoric acid, trimethylsilylester

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Letters in Organic Chemistry

Title: A Simple and Efficient Method for Trifluoroacetylation of Arylamines Using Trifluoroacetic Acid and Triphosgene

Volume: 8 Issue: 8

Author(s): Ki-Jong Han and Misoo Kim

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Abstract: A simple and efficient one-pot procedure for trifluoroacetylation of arylamines using trifluoroacetic acid and triphosgene is reported. A mixed trifluoroacetic anhydride generated in situ reacts with a variety of arylamines to give the corresponding trifluroacetamides in high yields.

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Han Ki-Jong and Kim Misoo, A Simple and Efficient Method for Trifluoroacetylation of Arylamines Using Trifluoroacetic Acid and Triphosgene, Letters in Organic Chemistry 2011; 8 (8) . https://dx.doi.org/10.2174/157017811797249317