Extended-Spectrum Cephalosporinases in Enterobacteriaceae

Title: Extended-Spectrum Cephalosporinases in Enterobacteriaceae

Volume: 6 Issue: 1

Author(s): Hedi Mammeri and Patrice Nordmann

Affiliation:

Keywords: ESAC, extended-spectrum cephalosporinase, cefepime, ceftazidime

Abstract: Extended-spectrum AmpC β-lactamases are derived from chromosomal cephalosporinases by amino acid deletion, insertion and replacement. These structural changes are responsible for an increased catalytic efficiency against extended- spectrum cephalosporins, such as ceftazidime, cefotaxime, cefepime, and cefpirome. An overview of the molecular and biochemical characterization of these identified β-lactamases in Enterobacteriaceae is provided. The structural modifications that account for the broadening substrate specificity and the phenotypes of resistance of the clinical isolates are detailed.

Cite this article as:

Mammeri Hedi and Nordmann Patrice, Extended-Spectrum Cephalosporinases in Enterobacteriaceae, Anti-Infective Agents in Medicinal Chemistry 2007; 6 (1) . https://dx.doi.org/10.2174/187152107779314133